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James Madison vs Louisville Prediction 9/5/2025 Today’s College Football Picks
Pick details
James Madison (1-0) vs Louisville (1-0)
September 5, 2025 at 07:00 PM EDT
The Line: Betting Odds: Louisville -14 — Over/Under: +57.5
James Madison and Louisville meet Friday in college football action from L&N Stadium. Here’s a James Madison vs Louisville prediction. We will look at this from a betting perspective and determine the best James Madison Dukes vs Louisville Cardinals pick. We will examine:
The James Madison Dukes’ recent form and player performance
The Louisville Cardinals’ recent form and player performance
Recent betting trends and streaks involving the Dukes
Recent betting trends and streaks involving the Cardinals
Recent betting trends in games played between James Madison and Louisville
A summary that ties it all together and produces a favorable betting outcome for the Dukes and Cardinals game.
This is a big-time test for James Madison, there is no other way to put it. This is a team that believes that they could be playing in the college football playoff, and if they want that to happen, this is a game that they need to win.
In the first game of the season, James Madison faced off against Weber State, and they were able to secure the 45-10 victory. At the end of the first quarter, they were up 14-0, and they never looked back on the way to the win. It was mostly a run-first attack, and as a team, they rushed for 313 yards. They also allowed Weber State to finish with only 148 yards. George Pettaway was the top rusher finishing with 10 rushes for 99 yards. They didn’t need much out of their quarterback, but Alonzo Barnett III completed 14 of his 22 passes for 130 yards and a touchdown.
Louisville has some expectations for this season, and a loss here would be devastating, even if James Madison is a good team. In the first game of the year, the Cardinals faced off against Eastern Kentucky, and they were able to pick up the 51-17 victory. At halftime, they were up 41-7, and in the second half, they didn’t have to do much, except take their foot off the gas a little. Even though they won, Louisville does need to do a little better job of not turning the ball over.
Quarterback Miller Moss completed 17 of his 25 passes for 223 yards, one touchdown, and two interceptions. Isaac Brown ran wild, and he finished the game with six carries for 126 yards and two touchdowns. They also allowed Eastern Kentucky to only finish with 76 yards through the air, but more importantly, in this game, they are going to need to slow down the run.
This line is CRAZY. James Madison has enough talent to make the college football playoff, and even though they are going on the road, you are telling me they are 14-point underdogs? Yeah, no chance. James Madison ran wild in the first game, and they are going to go wild again here. The turnovers were an issue for Moss in the first game for Louisville and that is going to be a major problem here. James Madison defense is good, and they are going to create a couple of turnovers here. Louisville might still win the game, but this is way too many points. Back James Madison against the spread.
The James Madison Dukes’ recent form and player performance
The Louisville Cardinals’ recent form and player performance
Recent betting trends and streaks involving the Dukes
Recent betting trends and streaks involving the Cardinals
Recent betting trends in games played between James Madison and Louisville
A summary that ties it all together and produces a favorable betting outcome for the Dukes and Cardinals game.
Big Time Test for James Madison
This is a big-time test for James Madison, there is no other way to put it. This is a team that believes that they could be playing in the college football playoff, and if they want that to happen, this is a game that they need to win.
In the first game of the season, James Madison faced off against Weber State, and they were able to secure the 45-10 victory. At the end of the first quarter, they were up 14-0, and they never looked back on the way to the win. It was mostly a run-first attack, and as a team, they rushed for 313 yards. They also allowed Weber State to finish with only 148 yards. George Pettaway was the top rusher finishing with 10 rushes for 99 yards. They didn’t need much out of their quarterback, but Alonzo Barnett III completed 14 of his 22 passes for 130 yards and a touchdown.
Louisville Can’t Slip Up
Louisville has some expectations for this season, and a loss here would be devastating, even if James Madison is a good team. In the first game of the year, the Cardinals faced off against Eastern Kentucky, and they were able to pick up the 51-17 victory. At halftime, they were up 41-7, and in the second half, they didn’t have to do much, except take their foot off the gas a little. Even though they won, Louisville does need to do a little better job of not turning the ball over.
Quarterback Miller Moss completed 17 of his 25 passes for 223 yards, one touchdown, and two interceptions. Isaac Brown ran wild, and he finished the game with six carries for 126 yards and two touchdowns. They also allowed Eastern Kentucky to only finish with 76 yards through the air, but more importantly, in this game, they are going to need to slow down the run.
James Madison vs Louisville Prediction
This line is CRAZY. James Madison has enough talent to make the college football playoff, and even though they are going on the road, you are telling me they are 14-point underdogs? Yeah, no chance. James Madison ran wild in the first game, and they are going to go wild again here. The turnovers were an issue for Moss in the first game for Louisville and that is going to be a major problem here. James Madison defense is good, and they are going to create a couple of turnovers here. Louisville might still win the game, but this is way too many points. Back James Madison against the spread.
