Philadelphia 76ers vs San Antonio Spurs Prediction 3/21/25 NBA Picks

San Antonio Spurs (29-39) vs Philadelphia 76ers (23-46)

Game Info: Friday, March 21, 2025 at 8:00 pm (Frost Bank Center)

Betting Odds: San Antonio Spurs -5.5 -- Over/Under: 240 Click Here for the Latest Odds

Where to Watch: FanDuel SN SW

The Philadelphia 76ers invade the Frost Bank Center to take on the San Antonio Spurs on Friday night. Here’s a Philadelphia 76ers vs San Antonio Spurs Prediction. This article will include a Philadelphia 76ers vs San Antonio Spurs Pick.
 

Philadelphia 76ers Betting Preview

The Philadelphia 76ers have been in terrible form as they've lost 17 of their last 20 games overall and they will be hoping to avoid a third straight defeat after getting routed by the Thunder in a 133-100 road defeat on Wednesday. Quentin Grimes led the team with 28 points on 10 of 21 shooting, Justin Edwards added 19 points while Chuma Okeke chipped in with 14 points, 15 rebounds and two assists off the bench. As a team, the 76ers shot just 36 percent from the field and 18 of 57 from the 3-point line as they struggled right from the start and leaked 42 points in the first quarter to fall behind by 14 points going into halftime. Things only got worse in the third quarter where they managed just 18 points and trailed by as many as 41 points at one stage. 

San Antonio Spurs Betting Preview

Meanwhile, the San Antonio Spurs have been in decent form lately as they've won three of their past five games overall. They will be eager to keep it going after blowing past the Knicks in a 120-105 home win on Wednesday. Sandro Mamukelashvili led the team in scoring with 34 points on 13 of 14 shooting off the bench, Stephon Castle added 22 points while Chris Paul chipped in with 12 points and nine assists. As a team, the Spurs shot 50 percent from the field and 16 of 35 from the 3-point line as they jumped all over the Knicks from the start and were always in complete control after dominating the first half by 67-43. The Spurs will play against the Raptors and Pistons following this one.

Why the San Antonio Spurs will win

  • The 76ers have lost each of their 10 previous night games at Frost Bank Center following a road loss.
  • The Spurs have won 11 of their last 12 home games against the 76ers following a home win.
  • The 76ers have failed to cover the spread in eight of their last nine night games against teams that held a losing record.
  • The Spurs have covered the spread in each of their last five night games against Atlantic Division opponents that held a losing record.

Why the Philadelphia 76ers will win

  • The Spurs have lost each of their last eight games after winning as underdogs.
  • The 76ers have won each of their last eight Friday games against the Spurs.
  • The Spurs have failed to cover the spread in 10 of their last 11 games following a win.
  • The 76ers have covered the spread in seven of their last eight road games against Southwest Division opponents that held a losing record.

Total Points Facts

  • Each of the Spurs' last eight games as home favorites against the 76ers have gone UNDER the total points line.
  • Each of the 76ers' last seven road games has gone OVER the total points line.

Philadelphia 76ers vs San Antonio Spurs Prediction

The 76ers are still missing a long list of players including Kelly Oubre Jr, Joel Embiid, Paul George, and Andre Drummond, while the Spurs are still playing without Victor Wembenyama, De'Aaron Fox, and Charles Bassey. You really couldn't back either side with any confidence these days, but the Spurs have found a bit of a spark lately. They looked great in their upset win over the Knicks on Wednesday, and I think they can maintain that momentum with a win and cover at home against this severely depleted 76ers squad.
 

Peter’s Pick San Antonio -5.5

Get Premium Picks Start Winning Now »
The pick in this article is the opinion of the writer, not a PickDawgz site consensus.

18+ Has gambling become a problem for you? Call the National Problem Gambling Hotline.
1-800-522-4700 | ncpgambling.org

Credit Guaranteed Packages

Packages with Credit Guarantees automatically give you a credit if the package does not turn a profit—the sum of betting all individual picks. THESE ARE NOT PARLAYS UNLESS OTHERWISE CLEARLY STATED. If a credit guaranteed package does not profit, a credit for its full purchase price is automatically issued after picks are graded and verified.

For example, if you purchase a $39.95 package that doesn’t profit, you’ll get a $39.95 credit towards any future purchase(s) on our site. Credits are usually issued within hours of a game’s conclusion, so please allow a few hours for final verification.

To use your credits, log in to your account and add another package or pass to your cart. Credits will automatically reduce what you owe. Any remaining balance will be settled through our payment system, with any leftover credits available future purchases. Credits do not expire.

Dismiss