Seahawks vs Cardinals Prediction 9/20/2026 Today’s NFL Picks

In this article we will formulate a Seahawks vs Cardinals prediction for this NFL game on Sunday, September 20th at State Farm Stadium in Glendale, Arizona. Let’s take a look at the prediction for this week 2 matchup.

Seattle Seahawks Betting Preview

The Seattle Seahawks are 1-0 this season after they defeated the Patriots by a score of 13-10 in week one. Seattle trailed 7-0 at halftime and 10-3 after three, but they scored 10 points in the fourth quarter for the comeback win. The Seahawks out gained NE by a total of 285-277, went 2-11 on third downs, and won the turnover battle by a total of 3-0 in the game. Drew Lock threw for 187 yards and one touchdown, while JSN caught eight passes for 122 yards and one score. Jadarian Price rushed 10 times for 52 yards in the win. 

The Seahawks were 14-3 last year and they finished first in the NFC West, which was two games ahead of the Rams in second. Seattle lost their first game of the season and they were just 3-2 through five weeks, but they won 11 of their last 12 games. The Seahawks ended the regular season by winning seven games in a row and they allowed 16 points or fewer in five of their last six. Seattle defeated the 49ers 41-6, defeated the Rams 31-27, and defeated the Patriots 29-13 in the playoffs, as they won the Super Bowl. The Seahawks scored 28.4 points per game in 2025, while they allowed 17.2 points against per game on defense, which was the best in the NFL. 

Arizona Cardinals Betting Preview

The Arizona Cardinals are 1-0 this year after they defeated the Chargers by a score of 26-14 last week. Arizona led 13-7 at halftime, but their lead was cut to 16-14 in the third, before scoring the last 10 points to seal the win. The Cardinals out gained LA by a total of 393-268, went 6-14 on third downs, and won the turnover battle by a total of 2-0 in the game. Jacoby Brissett threw for 277 yards and one touchdown, while Trey McBride caught nine passes for 95 yards and one score. Tyler Allgeier rushed 17 times for 61 yards in the win. 

The Cardinals went 3-14 last season and they finished fourth in the NFC West standings, 11 games behind the Seahawks. Arizona started the season with two wins over the Saints and Panthers, but it was all downhill after that point. The Cardinals lost 14 of their last 15 games, with their one win coming against the Cowboys. Arizona really struggled defensively last year, as they allowed 37+ points in four of their last five games. The Cardinals scored 20.9 points per game in 2025, while they allowed 28.7 points against per game on defense.

Why the Arizona Cardinals will win

• The Seahawks have lost eight of their nine previous road openers against NFC West opponents.
• The Cardinals have won seven of their last eight Week 2 home games against NFC opponents.
• The underdogs have covered the spread in six of the Seahawks’ last seven games at State Farm Stadium.
• The Seahawks have failed to cover the spread in five of their last six games against starting rookie QBs.
• The Seahawks have lost the first quarter in six of their last seven Week 2 road games against NFC opponents.
• The Cardinals have won the first half in each of their last six Week 2 home games.

Why the Seattle Seahawks will win

• The Cardinals have lost each of their last 11 Sunday games against opponents on a winning streak.
• The Seahawks have won each of their last 10 games following a win.
• The Seahawks have covered the spread in each of their last six games as favorites when playing with a rest advantage.
• The Cardinals have failed to cover the spread in seven of their last eight games at State Farm Stadium.
• The Cardinals have lost the first quarter in four of their last five home games against NFC West opponents.
• The Cardinals have lost the first half in 15 of their last 16 games as underdogs against NFC West opponents.

Total Points Facts

• Nine of the Cardinals’ last 10 Sunday home games have gone OVER the total points line.
• Eight of the Seahawks’ last nine September games against NFC West opponents have gone UNDER the total points line.
• Nine of the last 12 games between NFC West teams have gone OVER the total points line.

Arizona Cardinals Player Prop Facts

• Jacoby Brissett has recorded 22+ completions in each of the Cardinals’ last four games as underdogs against NFC West opponents.
• Jacoby Brissett has recorded 243+ passing yards in seven of the Cardinals’ last eight games as underdogs against NFC opponents.
• Kendrick Bourne has recorded 29+ rushing and receiving yards in seven of his last eight September appearances.
• Tyler Allgeier has recorded 34+ rushing yards in each of his last four Sunday appearances with his team as an underdog.
• James Conner has recorded 19+ receiving yards in each of his last six appearances against the Seahawks.
• James Conner has scored at least one touchdown in each of his last four appearances at State Farm Stadium.
• Heading into Week 2, Chad Ryland has recorded the equal-most made field goals in a single game this season (4 vs Chargers, Week 1).

Seattle Seahawks Player Prop Facts

• Drew Lock has recorded 21+ completions in six of his last seven appearances as a starter.
• Jaxon Smith-Njigba has recorded 84+ receiving yards in each of the Seahawks’ last four regular season games against NFC West opponents.
• Zach Charbonnet has scored at least one touchdown in each of his last four September appearances with the Seahawks as favorites.
• Zach Charbonnet has scored the first touchdown in each of the Seahawks’ last three regular season games against NFC opponents.
• Rashid Shaheed has recorded 33+ rushing and receiving yards in each of his last four September appearances against NFC opponents.
• Zach Charbonnet has recorded 37+ rushing yards in seven of the Seahawks’ last eight regular season games against NFC West opponents.
• Heading into Week 2, Brady Russell ranks T1st amongst qualified players for catch rate (100.0%) this season.

Matchup/League Facts

• Heading into Week 2, the Cardinals rank T1st in the NFL in Q2 win percentage (100.0) this season.
• Heading into Week 2, the Cardinals rank T1st in the NFL in Q4 win percentage (100.0) this season.
• Heading into Week 2, the Seahawks rank T1st in the NFL in 4th down percentage (100.0%) this season.
• Heading into Week 2, the Seahawks rank T1st in the NFL in Q4 win percentage (100.0) this season.

Seahawks vs Cardinals Prediction 

Arizona comes into this matchup after upsetting the Chargers last week and they will look for another upset here. The Cardinals were the much better team last week, but will face a very tough Seattle squad here. Seattle survived against New England in their first game, but they will be using a backup QB. The Seahawks played outstanding defense in that victory, but I am worried about Lock at quarterback. With that being said, I think we will see a lower scoring game and I like the under here.

David Racey's Pick: Under 40.5