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Buffalo Bills vs Indianapolis Colts Prediction NFL Picks 11/10/24

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Indianapolis Colts (4-5) vs Buffalo Bills (7-2)

Game Info: Sunday, November 10, 2024 at 1:00 pm (Lucas Oil Stadium)

The Line: Betting Odds: Indianapolis Colts +4 / Buffalo Bills -4 — Over/Under: 45.5

(Get latest betting odds)

In this article, we will formulate a Buffalo Bills vs Indianapolis Colts prediction for this NFL game on Sunday, November 10th at Lucas Oil Stadium in Indianapolis, Indiana. Let’s take a look at the prediction for this Week 10 matchup.

Buffalo Bills Betting Preview

The Buffalo Bills are 7-2 this season after they defeated Miami by a score of 30-27 in their last game. Buffalo trailed 10-6 at halftime and they were tied at 27 in the fourth, but they kicked the game-winning field goal with five seconds left for the win. The Bills were outgained by a total of 373-325, tied the turnover battle at one, and went 5-10 on third down in the game. Josh Allen threw for 235 yards, three touchdowns, and one interception, while Ray Davis caught two passes for 70 yards and one score. 

Prior to that game, the Bills won three games in a row against Seattle, Tennessee, and the Jets. The Buffalo offense has scored 28.9 points per game with 216.1 passing yards and 119.1 rushing yards per game, while the defense has allowed 19.2 points per game this season. Josh Allen has completed 64.1% of his passes for 2,001 yards, 17 touchdowns, and two interceptions, while Khalil Shakir has caught 42 passes for 471 yards and two scores. 

Indianapolis Colts Betting Preview

The Indianapolis Colts are 4-5 this year after they lost to Minnesota by a score of 21-13 in their last game. Indianapolis led 7-0 at the half, but they allowed 14 points in the third quarter and never got the lead back. The Colts were outgained by a total of 415-227, won the turnover battle 3-2, and went 3-11 on third down in the game. Joe Flacco threw for 179 yards and one interception, while Josh Downs caught six passes for 60 yards in the game. 

Prior to that loss, the Colts lost to Houston by a score of 23-20 but did beat Miami and Tennessee before that. The Indianapolis offense has scored 20.9 points per game with 193.7 passing yards and 121.3 rushing yards per game, while the defense has allowed 21.4 points per game this season. Joe Flacco has completed 64.4% of his passes for 895 yards, seven touchdowns, and two interceptions, while Jonathan Taylor has rushed for 502 yards and five scores. 

Why the Colts will cover

Total Points Facts

Indianapolis Colts Player Prop Facts

Buffalo Bills Player Prop Facts

Matchup/League Facts

Buffalo Bills vs Indianapolis Colts Prediction 

Buffalo rolls into this matchup looking for their fifth win in a row and they have scored 30+ points in three straight games. The Bills did play a close game against Miami last week and they are 3-2 on the road. Indianapolis has lost two games in a row, but they are 3-1 at home so far this year. The Colts are sticking with Joe Flacco at quarterback, but he didn’t look very good against Minnesota last week. This Colts offense is not my favorite and I question how Flacco will hold up as the season progresses, but I do think they can keep this game close, as their defense has been decent over the last month. Take Indianapolis with the points here. 

David Racey's Pick: Colts +4

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