Toronto Blue Jays vs Houston Astros Prediction 4/21/25 MLB Picks

In this article, we will formulate a Blue Jays vs Astros prediction for this MLB game on Monday, April 21, at Daikin Park in Houston, Texas. Let’s take a look at the prediction for this MLB matchup.

Toronto Blue Jays Betting Preview

The Toronto Blue Jays (12-10, 4-5 Away)spent the previous two series at home, where they beat the Braves and lost to the Mariners. Toronto opened the series against the Mariners with a win, but lost the next two. In the latest 8-3 loss, Easton Lucas took the loss after allowing six runs on seven hits with five strikeouts and two walks in 1.2 innings.

This year, the Blue Jays average 3.91 runs per game (21st in the MLB) on a .259/.333/.368 triple-slash. When it comes to pitching, the Blue Jays’ staff has a 3.58 ERA (8th) and 1.10 WHIP (4th). Bo Bichette leads the Blue Jays with a .313 batting average, no home runs, and 13 RBI this season.

Kevin Gausman will take the mound for the Blue Jays on Monday. The 34-year-old right-hander has a 2-1 record in four starts this year with a 2.49 ERA and 0.71 WHIP in 25.1 innings.

Houston Astros Betting Preview

The Houston Astros (10-11, 6-6 Home) have been fairly inconsistent so far in the season and managed to get back-to-back wins just once. The Astros opened the most recent home series against the Padres with 6-4 and 3-2 wins, but couldn’t get the first sweep of the campaign as they lost Game 3. In that 3-2 loss, Framber Valdez pitched for 6.0 innings in a no-decision, allowing two runs on seven hits with two strikeouts and three walks. Tayler Scott took the loss.

This season, the Astros average 3.67 runs per game (23rd in the MLB) on a .222/.299/.331 slash line. Regarding pitching, the Astros’ staff has a 3.63 ERA (10th) and 1.15 WHIP (7th). Isaac Paredes leads the Astros with a .231 batting average, three home runs, and 11 RBI this season.

The projected starting pitcher for the Astros is Hunter Brown, who is 2-1 in four starts this season, with a 1.50 ERA and 0.83 WHIP in 24.0 innings.

Total Runs Facts

• Each of the Blue Jays’ last four games as underdogs against American League opponents have gone OVER the total runs line.
• Five of the Astros’ last six night games after playing the previous day have gone UNDER the total runs line.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in seven of the Blue Jays’ last eight games.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in 11 of the Astros’ last 13 night games.

Matchup/League Facts

• The Astros rank 4th in the league for runs allowed this season (79).
• The Astros rank T26th in the league for hits this season (153).
• The Blue Jays rank 29th in the league for home runs allowed this season (31).
• The Blue Jays rank 3rd in the league for strikeouts this season (213).

Blue Jays vs Astros Prediction

The teams have traded victories in the past few years, as each recorded five wins in the last ten H2H encounters. The Astros did win four of the last five H2H duels. Seven of the previous ten H2H duels went Under, and considering the pitching matchup here, I am going with another low-scoring affair. Kevin Gausman allowed a .173 BA in 81 at-bats against the Astros, while Hunter Brown allowed a .250 BA in 32 at-bats against the Blue Jays. Brown registered all four quality starts this year and didn’t allow a single run in the last two. Back the Under.