| MATCHUP | St. Louis Cardinals | Miami Marlins |
|---|---|---|
| Team Records | 13-9 | 11-12 |
| Where | loanDepot park, Miami, Florida | |
| When | Tuesday, April 21, 2026 | |
| Time | 06:40 PM EDT | |
| TV | MLB.TV | |
In this article, we will formulate a Cardinals vs Marlins Prediction for this MLB matchup on Tuesday, April 21st in the second game of this series. Let’s take a look at the prediction for this MLB matchup.
Miami Marlins Preview
The Miami Marlins have a 11-12 record this season and are sitting in the second place of the NL East. They have a 9-5 home record and are coming off a 5-3 home win against the Cardinals. Their previous three games were a 5-3 home win, a 2-5 and a 5-7 home loss against the Brewers.
The Marlins have a .254 batting average this season, .330 OBP and .391 Slugging percentage. Miami’s pitching staff has a 4.01 ERA and 1.25 WHIP. Xavier Edwards is the team’s best hitter with a .341 batting average. Liam Hicks leads the team in RBI with 21, also adding a team‑high 4 home runs.
Chris Paddack (R) is the projected starting pitcher for the Marlins, and he has a 0-3 record, 5.59 ERA and 1.45 WHIP.
St. Louis Cardinals Preview
The St. Louis Cardinals have a 13-9 record this season and are sitting in the fourth place of the NL Central. They have a 6-4 away record and are coming off a 3-5 road loss against the Marlins. They won their previous three games on the road against the Astros by scores of 7-5, 7-5, and 9-4.
The Cardinals have a .230 batting average this season, .325 OBP and .373 Slugging percentage. St. Louis’ pitching staff has a 4.86 ERA and 1.42 WHIP. Jordan Walker is the team’s best hitter with a .306 batting average, also leading the team in RBI with 16 and adding a team‑high 8 home runs.
Dustin May (R) is the projected starting pitcher for the Cardinals, and he has a 2-2 record, 6.98 ERA and 1.60 WHIP.
St. Louis Cardinals @ Miami Marlins Betting Trends: April 21, 2026
- Probable Starting Pitcher: Chris Paddack Record this season: 0-3 ERA: 5.59
- Home Record: 0-1
- Last 5 against Cardinals: 1-1
Why the Miami Marlins will win
- The Marlins have won each of their last five games against National League opponents following a home win.
- The Cardinals have lost six of their last eight road games against National League opponents.
- The Cardinals have failed to cover the run line in four of their last five games as road underdogs against National League opponents.
- The Marlins have covered the run line in four of their last five home games after playing the previous day.
- The Cardinals have trailed after 5 innings in each of their last six games as road underdogs against National League opponents.
- Probable Starting Pitcher: Dustin May Record this season: 2-2 ERA: 6.98
- Road Record: 0-1
- Last 5 against Marlins: 2-1
Why the St. Louis Cardinals will win
- The Marlins have lost each of their last seven Tuesday night games as home favorites against NL Central opponents.
- The Cardinals have won each of their last four games as road underdogs against NL East opponents following a loss.
- The Marlins have failed to cover the run line in each of their last 15 Tuesday night games as favorites against National League opponents.
- The Cardinals have covered the run line in each of their last six night games at LoanDepot Park following a loss.
- The Cardinals have led after 5 innings in four of their last five road games.
Total Runs Facts
- Seven of the Cardinals’ last eight games as underdogs have gone OVER the total runs line.
- Three of the Marlins’ last four night games against NL Central opponents have gone OVER the total runs line.
- The ‘Inning 1 UNDER 0.5 runs’ market has hit in seven of the Marlins’ last eight night games at LoanDepot Park.
- The ‘Inning 1 OVER 0.5 runs’ market has hit in four of the Cardinals’ last five night games.
Miami Marlins Player Prop Facts
- Kyle Stowers has hit at least one home run in eight of his last 21 home appearances.
- Chris Paddack has recorded seven or more strikeouts in four of his five previous appearances in night games against NL Central teams that held a winning record.
- Agustin Ramirez has recorded a hit in each of the Marlins’ last seven night games against NL Central opponents that held a winning record.
- Xavier Edwards ranks 3rd amongst qualified players for Batting Average (.341) this season.
St. Louis Cardinals Player Prop Facts
- Dustin May has recorded five or more strikeouts in four of his last five appearances against NL opponents that held a losing record.
- Lars Nootbaar has hit a home run in three of his last four Tuesday appearances against NL East teams that held a losing record.
- Lars Nootbaar has recorded at least one hit in each of his last nine road appearances against NL East opponents.
- Jordan Walker ranks T3rd in the league in Home Runs (8) this season.
Matchup/League Facts
- The Marlins rank 1st in the league for triples this season (8).
- The Marlins rank 3rd in the league for steals this season (26).
- The Cardinals rank 30th in the league for strikeouts this season (140).
- The Cardinals rank T27th in the league for doubles this season (28).
Cardinals vs Marlins Prediction
The Marlins are 6-3 in their last 9 meetings against the Cardinals and are 4-2 in their last 6 meetings in Miami.
In this Cardinals vs Marlins Prediction, the Marlins are coming as -112 home favorites. Miami won yesterday’s game and snapped St. Louis’ five-game winning streak, but I don’t trust either pitcher in this matchup. They both have a 12.57 ERA combined and 1.45+ WHIP each and the Cardinals are 26th in bullpen ERA. Both teams also are 12-4 to the over in their last 16 games combined, so I expect another high-scoring affair. Take the over 8.5 in this one.