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San Francisco Giants vs Washington Nationals Prediction 5/23/25 MLB Picks

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Washington Nationals (23-27) vs San Francisco Giants (29-21)

Game Info: Friday, May 23, 2025 at 6:45 pm (Nationals Park)

The Line: Betting Odds: Washington Nationals -108 / San Francisco Giants -112 — Over/Under: 8

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The San Francisco Giants and Washington Nationals meet Friday in MLB action at Nationals Park. Here’s a San Francisco Giants vs Washington Nationals Prediction. This article will include a San Francisco Giants vs Washington Nationals Pick.

San Francisco Giants Betting Preview

The San Francisco Giants are 29-21 on the year and play the Tigers, Marlins, and Padres next. The San Francisco Giants are batting .236 on the season, have a .313 OBP, and a .388 slugging percentage. The San Francisco Giants’ pitching staff has a 3.34 ERA and a 1.23 WHIP. Heliot Ramos leads the San Francisco Giants with 55 hits and 26 RBI, while Jung Hoo Lee and Wilmer Flores have combined for 98 hits and 73 RBI. 

Landen Roupp gets the ball for the San Francisco Giants, and he is 2-3 with a 4.11 ERA and 47 strikeouts this season. Roupp is 0-0 with a 10.80 ERA and 1 strikeout in his career against the Washington Nationals.

Washington Nationals Betting Preview

The Washington Nationals are 23-27 on the year and play the Mariners, Diamondbacks, and Cubs next. The Washington Nationals are batting .43 on the season, have a .313 OBP, and a .391 slugging percentage. The Washington Nationals’ pitching staff has a 5.24 ERA and a 1.44 WHIP. James Wood leads the Washington Nationals with 55 hits and 33 RBI, while Keibert Ruiz and CJ Abrams have combined for 93 hits and 39 RBI.

MacKenzie Gore gets the ball for the Washington Nationals, and he is 2-4 with a 3.67 ERA and 84 strikeouts this season. Gore is 3-1 with a 6.05 ERA and 22 strikeouts in his career against the San Francisco Giants.

Why the Washington Nationals will win

Why the San Francisco Giants will win

Washington Nationals Player Prop Facts

San Francisco Giants Player Prop Facts

San Francisco Giants vs Washington Nationals Prediction

The Nationals have won five straight games, and their offense is absolutely steamrolling during this stretch. Gore leads baseball in strikeouts, and through 24.2 home innings, he has a 2.92 ERA and .176 allowed batting average. Roupp has been hittable all season, especially on the road, where he has a 5.04 ERA and .260 allowed batting average. Roupp is allowing a .272 batting average on the season. I’ll ride the hot hand with the Nats and the more trustworthy pitcher in terms of the road/home splits. 

Randy Chambers's Pick: Washington Nationals -108

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