San Francisco Giants vs Washington Nationals Prediction 5/23/25 MLB Picks

The San Francisco Giants and Washington Nationals meet Friday in MLB action at Nationals Park. Here’s a San Francisco Giants vs Washington Nationals Prediction. This article will include a San Francisco Giants vs Washington Nationals Pick.

San Francisco Giants Betting Preview

The San Francisco Giants are 29-21 on the year and play the Tigers, Marlins, and Padres next. The San Francisco Giants are batting .236 on the season, have a .313 OBP, and a .388 slugging percentage. The San Francisco Giants’ pitching staff has a 3.34 ERA and a 1.23 WHIP. Heliot Ramos leads the San Francisco Giants with 55 hits and 26 RBI, while Jung Hoo Lee and Wilmer Flores have combined for 98 hits and 73 RBI. 

Landen Roupp gets the ball for the San Francisco Giants, and he is 2-3 with a 4.11 ERA and 47 strikeouts this season. Roupp is 0-0 with a 10.80 ERA and 1 strikeout in his career against the Washington Nationals.

Washington Nationals Betting Preview

The Washington Nationals are 23-27 on the year and play the Mariners, Diamondbacks, and Cubs next. The Washington Nationals are batting .43 on the season, have a .313 OBP, and a .391 slugging percentage. The Washington Nationals’ pitching staff has a 5.24 ERA and a 1.44 WHIP. James Wood leads the Washington Nationals with 55 hits and 33 RBI, while Keibert Ruiz and CJ Abrams have combined for 93 hits and 39 RBI.

MacKenzie Gore gets the ball for the Washington Nationals, and he is 2-4 with a 3.67 ERA and 84 strikeouts this season. Gore is 3-1 with a 6.05 ERA and 22 strikeouts in his career against the San Francisco Giants.

Why the Washington Nationals will win

• The underdogs have won each of the Nationals’ last five games.
• The Giants have lost each of their last three games as road favorites.
• The Nationals have covered the run line in each of their last six games as underdogs against NL West opponents.
• The Giants have failed to cover the run line in each of their last five games.
• The Giants have trailed after 5 innings in four of their last five games as road favorites.
• The Giants have trailed after 3 innings in four of their last five games as road favorites.

Why the San Francisco Giants will win

• The Giants have won 10 of their last 11 games following a home loss.
• The Nationals have lost eight of their last nine night games at Nationals Park following an extra-innings win.
• The Giants have covered the run line in seven of their last eight night games against National League opponents following a loss.
• The Nationals have failed to cover the run line in each of their last five games as underdogs after going to extra innings.
• The Giants have led after 3 innings in each of their last three games against National League opponents that held a losing record.
• The Giants have led after 5 innings in each of their last three games as favorites against National League opponents.

Washington Nationals Player Prop Facts

• Keibert Ruiz has recorded a Double in each of the Nationals’ last three games as underdogs against NL opponents.
• Luis Garcia has recorded at least one RBI in each of the Nationals’ last four games.
• MacKenzie Gore has recorded a win in each of his three previous appearances with his team as an underdog against the Giants.
• CJ Abrams has scored a run in four of his last five appearances against NL West opponents.
• MacKenzie Gore has recorded seven or more strikeouts in seven of his last eight appearances.
• CJ Abrams has recorded at least one hit in each of his last 12 appearances in night games against NL teams that held a winning record.
• Amed Rosario has recorded at least one Single in each of his last six appearances.
• Paul DeJong has hit a home run in each of his last two appearances with his team as an underdog against the Giants.
• CJ Abrams ranks 7th amongst qualified players for Slugging Percentage (.561) this season.

San Francisco Giants Player Prop Facts

• Jung Hoo Lee has hit a home run in each of the Giants’ last two games against NL opponents.
• Heliot Ramos has recorded a Double in three of the Giants’ last four road games against opponents that held a losing record.
• Matt Chapman has recorded at least one RBI in four of the Giants’ last five games as road favorites against NL East opponents.
• Heliot Ramos has scored at least one run in each of the Giants’ last seven games as road favorites against NL opponents.
• Heliot Ramos has recorded a Single in each of the Giants’ last seven games.
• Matt Chapman has recorded at least one hit in each of the Giants’ last eight games against NL East opponents.

San Francisco Giants vs Washington Nationals Prediction

The Nationals have won five straight games, and their offense is absolutely steamrolling during this stretch. Gore leads baseball in strikeouts, and through 24.2 home innings, he has a 2.92 ERA and .176 allowed batting average. Roupp has been hittable all season, especially on the road, where he has a 5.04 ERA and .260 allowed batting average. Roupp is allowing a .272 batting average on the season. I’ll ride the hot hand with the Nats and the more trustworthy pitcher in terms of the road/home splits.