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San Diego Padres vs Colorado Rockies Prediction 4/22/2026 Today’s MLB Picks

Apr 21, 2026; Denver, Colorado, USA; Colorado Rockies and San Diego Padres fans with the 999 challenge hot dog and beer food during the game at Coors Field. Mandatory Credit: Ron Chenoy-Imagn Images

Apr 21, 2026; Denver, Colorado, USA; Colorado Rockies and San Diego Padres fans with the 999 challenge hot dog and beer food during the game at Coors Field. Mandatory Credit: Ron Chenoy-Imagn Images

MATCHUP San Diego Padres Colorado Rockies
Team Records 16-7 9-15
Spread -1.5 -108 +1.5 -112
Moneyline -163 +135
Total Over 12 (-108) Under 12 (-112)
Where Coors Field, Denver, Colorado
When Wednesday, April 22, 2026
Time 08:40 PM EDT
TV MLB.TV
The San Diego Padres and Colorado Rockies meet Wednesday in MLB action at Coors Field. Here’s a San Diego Padres vs. Colorado Rockies Prediction. This article will include a San Diego Padres vs. Colorado Rockies Pick.

San Diego Padres Betting Preview


The San Diego Padres are 16-7 on the year and play the Cubs and Diamondbacks next. The San Diego Padres are batting. 230 on the season, have a .307 OBP, and have a .364 slugging percentage. The San Diego Padres pitching staff has a 3.22 ERA and a 1.19 WHIP. Fernando Tatis Jr. leads the San Diego Padres with 22 hits and 12 RBI, while Ramon Laureano and Xander Bogaerts have combined for 43 hits and 29 RBI.

Walker Buehler gets the ball for the San Diego Padres, and he is 1-1 with a 4.58 ERA and 18 strikeouts this season. Buehler is 7-4 with a 4.48 ERA and 128 strikeouts in his career against the Colorado Rockies.

Colorado Rockies Betting Preview


The Colorado Rockies are 9-15 on the year and play the Reds and Mets next. The Colorado Rockies are batting .238 on the season and have a .304 OBP, and a .380 slugging percentage. The Colorado Rockies pitching staff has a 4.26 ERA and a 1.40 WHIP. Troy Johnston leads the Colorado Rockies with 21 hits and 10 RBI while TJ Rumfield and Hunter Goodman have combined for 40 hits and 19 RBI.

Tomoyuki Sugano gets the ball for the Colorado Rockies, and he is 1-1 with a 3.92 ERA and 15 strikeouts this season. This will be Sugano’s second career game against the San Diego Padres.

Why the Colorado Rockies will win

Why the San Diego Padres will win

Total Runs Facts

Colorado Rockies Player Prop Facts

San Diego Padres Player Prop Facts

Matchup/League Facts

San Diego Padres vs Colorado Rockies Prediction


Sugano has been solid through 20.2 innings, but it’s not enough for me to step in front of the Padres. I keep saying it, but the Padres have some magic to them and they keep winning. Until that stops, I’m going to keep backing the Padres. The sample size is still fairly small, but the Padres are getting it done and oozing with confidence. Give me the Padres to keep things rolling, especially with prices that are more than reasonable.

Randy Chambers's Pick: San Diego Padres

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