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Philadelphia Phillies vs New York Mets Prediction 4/22/25 MLB Picks

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New York Mets (16-7) vs Philadelphia Phillies (13-10)

Game Info: Tuesday, April 22, 2025 at 7:10 pm (Citi Field)

The Line: Betting Odds: New York Mets +110 / Philadelphia Phillies -130 — Over/Under: 7.5

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The Philadelphia Phillies and the New York Mets meet Tuesday in MLB action from Citi Field. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Philadelphia Phillies vs. New York Mets prediction.

Starting Pitching Matchup

The Philadelphia Phillies will send out Cristopher Sanchez for the start here, and Sanchez is 2-0 with a 2.96 ERA and 31 strikeouts this season. In his last five starts against the Mets, Sanchez is 2-1 with a 3.34 ERA and 33 strikeouts. Griffin Canning will get the start for the Mets here and is 2-1 with a 3.43 ERA and 21 strikeouts this season. This will be Canning’s second career start against the Phillies.

Philadelphia Phillies Recap

The Philadelphia Phillies come into this game looking to bounce back from a 5-4 loss in Monday’s series opener to slip to 13-10 on the year. After this series, the Phillies will head on the road for a weekend series with the Chicago Cubs.

Phillies Drop Back-To-Back Games

Nick Castellanos has a team-high 24 hits with 6 doubles, including 3 home runs and 14 RBIs, while Kyle Schwarber has 22 hits with a team-high 7 home runs and 16 RBIs as well on the year. Bryce Harper has 5 stolen bases, 5 home runs, and 14 RBIs. Trea Turner also has 21 hits with a team-high 6 stolen bases. Max Kepler has 6 doubles and Bryson Stott has 4 doubles, 2 homers, and 13 RBIs, while Stott and J.T. Realmuto also have 4 stolen bases apiece this season.

Why the Philadelphia Phillies will win

Philadelphia Phillies Player Prop Facts

New York Mets Recap

The New York Mets come into this game looking to add on to their series-opening win over the Phillies from Monday’s matchup to improve to 16-7 on the year. After this series, the Mets will head on the road for a series against the Washington Nationals.

Mets Win 5th In A Row

Pete Alonso has a team-high 28 hits with 9 doubles, 6 home runs, 24 RBIs, and a .341 batting average, while Juan Soto has 20 hits with 5 doubles, 3 home runs, and 12 RBIs on the year. Francisco Lindor has 25 hits with a pair of stolen bases along with 4 doubles, 5 home runs, and 13 RBIs, while Brandon Nimmo has a team-high 19 strikeouts so far this season. Nimmo has also added 18 hits with 3 doubles and 4 home runs, and 10 RBIs this season. Luis Torrens has also chipped in 6 doubles, and Luisangel Acuna has 6 stolen bases as well this season.

Why the New York Mets will win

New York Mets Player Prop Facts

Total Runs Facts

Philadelphia Phillies vs. New York Mets Prediction

I’m on the Phillies here. I think that if there’s a spot for the Phillies to get one in this set, it’s here, as the Phillies had some late momentum with a rally before falling short in Monday’s matchup. Canning is still a pitcher I’m not 100% sold on in this Mets’ rotation, and Sanchez is cementing himself as one of the better lefty starters in baseball this season. I think the Phillies can get it done to even up the series. Give me the Phillies.

Chris Ruffolo's Pick: Philadelphia Phillies -130

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