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Philadelphia Phillies vs Cleveland Guardians Prediction 5/11/25 MLB Picks

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Cleveland Guardians (23-16) vs Philadelphia Phillies (23-16)

Game Info: Sunday, May 11, 2025 at 7:00 pm (Progressive Field)

The Line: Betting Odds: Cleveland Guardians +142 / Philadelphia Phillies -170 — Over/Under: 7.5

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The Philadelphia Phillies and Cleveland Guardians meet Sunday in MLB action at Progressive Field. Here’s a Philadelphia Phillies vs Cleveland Guardians Prediction. This article will include a Philadelphia Phillies vs Cleveland Guardians Pick.

Philadelphia Phillies Betting Preview

The Philadelphia Phillies are 23-16 on the year and play the Cardinals, Pirates, and Rockies next. The Philadelphia Phillies are batting .259 on the season, have a .338 OBP, and a .403 slugging percentage. The Philadelphia Phillies pitching staff has a 3.86 ERA and a 1.27 WHIP. Trea Turner leads the Philadelphia Phillies with 48 hits and 14 RBI, while Nick Castellanos and Kyle Schwarber have combined for 79 hits and 50 RBI. 

Zack Wheeler gets the ball for the Philadelphia Phillies, and he is 3-1 with a 3.35 ERA and 66 strikeouts this season. Wheeler is 0-2 with a 2.25 ERA and 11 strikeouts in his career against the Cleveland Guardians.

Cleveland Guardians Betting Preview

The Cleveland Guardians are 23-16 on the year and play the Brewers, Reds, and Twins next. The Cleveland Guardians are batting .237 on the season, have a .310 OBP, and a .388 slugging percentage. The Cleveland Guardians’ pitching staff has a 4.26 ERA and a 1.43 WHIP. Steven Kwan leads the Cleveland Guardians with 50 hits and 17 RBI, while Jose Ramirez and Gabriel Arias have combined for 72 hits and 34 RBI.

Luis Ortiz gets the ball for the Cleveland Guardians, and he is 2-3 with a 5.30 ERA and 40 strikeouts this season. Ortiz is 2-0 with a 0.69 ERA and 7 strikeouts in his career against the Philadelphia Phillies.

Why the Cleveland Guardians will win

Why the Philadelphia Phillies will win

Cleveland Guardians Player Prop Facts

Philadelphia Phillies Player Prop Facts

Philadelphia Phillies vs Cleveland Guardians Prediction

It’s hard to go against the Phillies in this spot as they’ve caught fire over the last couple of weeks, and Wheeler has been one of the best pitchers in baseball. Wheeler is second in strikeouts and has a top-10 WHIP at 0.94. Wheeler has gone at least six innings in each of his last four starts and has allowed no more than two runs in all of those games. Ortiz has had some promising performances, but he’s also allowed four or more runs in two of his last three starts. Ortiz is coming off a bad performance against the Nationals, where he allowed five hits and five earned runs in 5.1 innings while walking three. I’m going to side with the Phillies and lay the RL to shave down the price.

Randy Chambers's Pick: Philadelphia Phillies -1.5

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