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New York Yankees vs Cleveland Guardians Prediction 4/22/25 MLB Picks

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Cleveland Guardians (13-9) vs New York Yankees (14-9)

Game Info: Tuesday, April 22, 2025 at 6:10 pm (Progressive Field)

The Line: Betting Odds: Cleveland Guardians -105 / New York Yankees -115 — Over/Under: 8

(Get latest betting odds)

The New York Yankees and Cleveland Guardians meet Tuesday in MLB action at Progressive Field. Here’s a New York Yankees vs Cleveland Guardians Prediction. This article will include a New York Yankees vs Cleveland Guardians Pick.

New York Yankees Betting Preview

The New York Yankees are 14-9 on the year and play the Blue Jays, Orioles, and Rays next. The New York Yankees are batting .258 on the season, have a .342 OBP, and a .468 slugging percentage. The New York Yankees’ pitching staff has a 4.10 ERA and a 1.23 WHIP. Aaron Judge leads the New York Yankees with 33 hits and 25 RBI, while Paul Goldschmidt and Ben Rice have combined for 51 hits and 16 RBI. 

Will Warren gets the ball for the New York Yankees, and he is 1-0 with a 5.17 ERA and 16 strikeouts this season. This will be Warren’s first career game against the Cleveland Guardians.

Cleveland Guardians Betting Preview

The Cleveland Guardians are 13-9 on the year and play the Red Sox, Twins, and Blue Jays next. The Cleveland Guardians are batting .240 on the season, have a .313 OBP, and a .402 slugging percentage. The Cleveland Guardians’ pitching staff has a 3.98 ERA and a 1.35 WHIP. Steven Kwan leads the Cleveland Guardians with 29 hits and 14 RBI, while Jose Ramirez and Carlos Santana have combined for 40 hits and 19 RBI.

Tanner Bibee gets the ball for the Cleveland Guardians, and he is 1-2 with a 5.85 ERA and 15 strikeouts this season. This will be Bibee’s second career game against the New York Yankees.

Why the Cleveland Guardians will win

Why the New York Yankees will win

Cleveland Guardians Player Prop Facts

New York Yankees Player Prop Facts

New York Yankees vs Cleveland Guardians Prediction

Warren isn’t a pitcher I’m excited to get behind as he’s been a disaster through nine career starts. In 38.1 innings, Warren has an 8.22 ERA and 1.70 WHIP. Bibee is the more trustworthy pitcher overall, but he’s struggled this year with a 5.85 ERA and 1.50 WHIP through 20 innings. The difference is that the Yankees have a more consistent lineup to back up potential struggles. Also, the Yankees have bounced back nicely this season after losses. If forced to pick a side between two struggling pitchers, I want the better offense. Give me the Yankees and the reasonable price.

Randy Chambers's Pick: New York Yankees -115

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