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Minnesota Twins vs Washington Nationals Prediction 5/6/2026 Today’s MLB Picks

May 5, 2026; Washington, District of Columbia, USA;  Minnesota Twins catcher Ryan Jeffers (27) reacts after hitting a double against the Washington Nationals during the seventh inning at Nationals Park. Mandatory Credit: Rafael Suanes-Imagn Images

May 5, 2026; Washington, District of Columbia, USA; Minnesota Twins catcher Ryan Jeffers (27) reacts after hitting a double against the Washington Nationals during the seventh inning at Nationals Park. Mandatory Credit: Rafael Suanes-Imagn Images

MATCHUP Minnesota Twins Washington Nationals
Team Records 16-20 16-20
Spread -1.5 119 +1.5 -143
Moneyline -136 +113
Total Over 9.5 (-105) Under 9.5 (-115)
Where Nationals Park, Washington, District of Columbia
When Wednesday, May 6, 2026
Time 06:45 PM EDT
TV ESPN Unlmtd
The Minnesota Twins and Washington Nationals meet Wednesday in MLB action at Nationals Park. Here’s a Minnesota Twins vs. Washington Nationals Prediction. This article will include a Minnesota Twins vs. Washington Nationals Pick.

Minnesota Twins Betting Preview


The Minnesota Twins are 16-20 on the year and play the Marlins and Guardians next. The Minnesota Twins are batting .236 on the season and have a .328 OBP, and a .384 slugging percentage. The Minnesota Twins pitching staff has a 4.41 ERA and a 1.36 WHIP. Byron Buxton leads the Minnesota Twins with 35 hits and 17 RBI, while Luke Keaschall and Brooks Lee have combined for 61 hits and 36 RBI.

Bailey Ober gets the ball for the Minnesota Twins, and he is 3-1 with a 3.55 ERA and 29 strikeouts this season. This will be Ober’s second career game against the Washington Nationals.

Washington Nationals Betting Preview


The Washington Nationals are 16-20 on the year and play the Marlins and Reds next. The Washington Nationals are batting .237 on the season and have a .317 OBP, and a .380 slugging percentage. The Washington Nationals pitching staff has a 4.90 ERA and a 1.46 WHIP. Daylen Lile leads the Washington Nationals with 35 hits and 14 RBI while James Wood and CJ Abrams have combined for 67 hits and 53 RBI.

Miles Mikolas gets the ball for the Washington Nationals, and he is 0-3 with an 8.23 ERA and 19 strikeouts this season. Mikolas is 0-1 with a 3.09 ERA and 9 strikeouts in his career against the Minnesota Twins.

Why the Washington Nationals will win

Why the Minnesota Twins will win

Total Runs Facts

Washington Nationals Player Prop Facts

Minnesota Twins Player Prop Facts

Matchup/League Facts

Minnesota Twins vs Washington Nationals Prediction


The Nationals are quiet offensively this week, scoring 3 or fewer runs in each of their last 4 games. That’s not going to cut it with Mikolas on the mound given his 8.23 ERA and 1.72 WHIP in 27.1 innings. Ober has a 3.18 ERA in his last 34 innings with 28 strikeouts. It’s hard to get behind the Nationals in this spot, as Mikolas looks like a shell of himself these days. Give me the Twins and the better pitcher on the bump.

Randy Chambers's Pick: Minnesota Twins

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