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Minnesota Twins vs New York Mets Prediction 4/22/2026 Today’s MLB Picks

Apr 21, 2026; New York City, New York, USA;  A fan wears a bag in the eighth inning during a game between the Minnesota Twins and the New York Mets at Citi Field. Mandatory Credit: Wendell Cruz-Imagn Images

Apr 21, 2026; New York City, New York, USA; A fan wears a bag in the eighth inning during a game between the Minnesota Twins and the New York Mets at Citi Field. Mandatory Credit: Wendell Cruz-Imagn Images

MATCHUP Minnesota Twins New York Mets
Team Records 12-11 7-16
Where Citi Field, Queens, New York
When Wednesday, April 22, 2026
Time 07:10 PM EDT
TV MLB.TV
The Minnesota Twins and New York Mets meet Wednesday in MLB action at Citi Field. Here’s a Minnesota Twins vs. New York Mets Prediction. This article will include a Minnesota Twins vs. New York Mets Pick.

Minnesota Twins Betting Preview


The Minnesota Twins are 12-11 on the year and play the Rays and Mariners next. The Minnesota Twins are batting .228 on the season and have a .329 OBP, and a .378 slugging percentage. The Minnesota Twins pitching staff has a 4.01 ERA and a 1.34 WHIP. Josh Bell leads the Minnesota Twins with 20 hits and 15 RBI, while Luke Keaschall and Byron Buxton have combined for 40 hits and 18 RBI.

Connor Prielipp will make his major league debut when he takes the mound tonight. Prielipp was 2-10 with a 3.72 ERA and 168 strikeouts in his minor-league career. In two seasons at Alabama, Prielipp was 4-1 with a 0.96 ERA and 47 strikeouts. 

New York Mets Betting Preview


The New York Mets are 7-16 on the year and play the Rockies and Nationals next. The New York Mets are batting. 222 on the season, have a .285 OBP, and have a .332 slugging percentage. The New York Mets pitching staff has a 4.10 ERA and a 1.27 WHIP. Bo Bichette leads the New York Mets with 21 hits and 9 RBI, while Francisco Lindor and Luis Robert Jr. have combined for 37 hits and 11 RBI.

Clay Holmes gets the ball for the New York Mets, and he is 2-2 with a 1.96 ERA and 16 strikeouts this season. Holmes is 3-1 with a 1.76 ERA and 15 strikeouts in his career against the Minnesota Twins.

Why the New York Mets will win

Why the Minnesota Twins will win

Total Runs Facts

New York Mets Player Prop Facts

Minnesota Twins Player Prop Facts

Matchup/League Facts

Minnesota Twins vs New York Mets Prediction


Usually I have a thing about fading pitchers making their big league debut because we have no idea how they’re going to look. I like sample sizes. However, seeing the Mets in the favorite role when they haven’t won a game in more than two weeks is crazy. The Mets looked like they were going to end the skid last night and blew it. At this point it’s in their head. Also, Prielipp is a top-five prospect in the Twins farm system, so he has above-average stuff that could shine early. I’m not laying juju with a team that’s lost 12 straight games. Give me the Twins.

Randy Chambers's Pick: Minnesota Twins

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