Giants vs Cubs Prediction 5/5/25 MLB Picks

In this article, we will formulate a Giants vs Cubs prediction for this MLB game on Monday, May 5th at Wrigley Field in Chicago, Illinois. Let’s take a look at the prediction for this MLB matchup. 

San Francisco Giants Betting Preview

The San Francisco Giants are 22-13 this year after they won three out of four against the Rockies by scores of 3-4, 4-0, 6-3, and 9-3. In their game four win, San Francisco had their lead cut to 2-1 in the fifth inning, but they answered with seven straight runs to pull away for the blowout win. The Giants recorded 13 hits and they committed two errors in the game, while they were led by Adames, who went 3-5 with two home runs and three RBIs in the win. San Francisco started Webb, who allowed six hits and one earned run over 7.0 innings for the win, while Bivens allowed two hits and two earned runs in one relief inning. 

Prior to that series, the Giants lost both games against the Padres, but did win two out of three against the Rangers before that. San Francisco has won five of their last eight games, and they are currently third in the NL West standings. The San Francisco pitching staff has a 3.44 ERA with a 1.23 WHIP, and a .233 opponent batting average, while the offense has scored 164 runs with a .231 batting average and a .310 on-base percentage this season. Wilmer Flores has led San Francisco with seven home runs and 31 RBIs, while Matt Chapman has added seven home runs and 21 RBIs this year. The projected starting pitcher for San Francisco is Landen Roupp, who is 2-2 with a 5.10 ERA and a 1.63 WHIP over 30.0 innings pitched this year. 

Chicago Cubs Betting Preview

The Chicago Cubs are 21-14 this season after they won two out of three against the Brewers by scores of 10-0, 6-2, and 0-4. In their game three loss, Chicago pitched a great game, but they allowed four runs in the sixth inning, which was the difference in the loss. The Cubs recorded five hits in the game, and they were led by Tucker, who went 2-3 in the loss. Chicago started Imanaga, who allowed four hits and two earned runs over 5.2 innings in the loss, while Merryweather allowed two hits and two earned runs over just 0.1 inning of relief. 

Prior to that series, the Cubs won two out of three against the Pirates, but did lose two out of three against the Phillies before that. Chicago has won four of their last six games, and they are currently first in the NL Central standings. The Chicago pitching staff has a 3.82 ERA with a 1.30 WHIP and a .241 opponent batting average, while their offense has scored 208 runs with a .262 batting average and a .339 on-base percentage this season. Kyle Tucker has led Chicago with nine home runs and 30 RBIs, while Seiya Suzuki has added nine home runs and 29 RBIs this year. The projected starting pitcher for Chicago is Matthew Boyd, who is 2-2 with a 2.70 ERA and a 1.44 WHIP over 33.1 innings pitched this season. 

Why the Cubs will beat the Giants 

• The Cubs have won each of their last eight games against National League opponents following a road loss.
• The Giants have lost each of their last seven games at Wrigley Field against teams that held a winning record.
• The Giants have failed to cover the run line in each of their last six night games against National League opponents following a home win.
• The Cubs have covered the run line in four of their last five games against National League opponents following a road loss.
• The Cubs have led after 3 innings in six of their last seven games at Wrigley Field against NL West opponents that held a winning record.
• The Cubs have led after 5 innings in seven of their last eight home games against NL West opponents.

Total Runs Facts

• Each of the Giants’ last 10 games as road underdogs have gone OVER the total runs line.
• Four of the Cubs’ last five games as favorites against the Giants have gone OVER the total runs line.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in 10 of the last 11 night games between the Giants and Cubs.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in nine of the Giants’ last 10 games as underdogs against NL Central opponents.

Chicago Cubs Player Prop Facts

• Dansby Swanson has hit a home run in each of the Cubs’ last two games against the Giants at Wrigley Field.
• Kyle Tucker has recorded an RBI in each of the Cubs’ last four night games.
• Ian Happ has scored a run in each of the Cubs’ last four night games.
• Nico Hoerner has recorded at least one Single in eight of the Cubs’ last nine games against the Giants.
• Nico Hoerner has recorded at least one hit in each of his last 11 Monday appearances with the Cubs as favorites.
• Seiya Suzuki ranks T6th in the league in Home Runs (9) this season.

San Francisco Giants Player Prop Facts

• Wilmer Flores has recorded at least one RBI in six of the Giants’ last seven night games against NL teams that held a winning record.
• Heliot Ramos has scored at least one run in 12 of the Giants’ last 13 road games against NL opponents.
• Jung Hoo Lee has recorded at least one Single in each of his last nine appearances with the Giants as road underdogs against NL opponents.
• Heliot Ramos has recorded at least one hit in each of the Giants’ last 12 road games against NL opponents that held a winning record.
• Mike Yastrzemski has hit a home run in two of his last three road appearances against NL Central opponents that held a winning record.

Matchup/League Facts

• The Cubs rank T1st in the league for triples this season (9).
• The Cubs rank 1st in the league for RBIs this season (204).
• The Giants rank T6th in the league for strikeouts this season (305).
• The Giants rank 24th in the league for batting average this season (.231).

Giants vs Cubs Prediction 

These two teams come into this series with very similar records on the season, but Chicago will be at home, where they are 9-7 this year. The Cubs are the highest scoring team in the MLB so far this season, and they have scored at least six runs in three of their last four games. Chicago is starting Boyd, who has allowed two earned runs or fewer in three of his last five starts. SF is going with Roupp, who has allowed three earned runs or more in three of his last four starts. I think the Cubs have the slight advantage in this game, and I like them to win here. 

David Racey's Pick: Cubs ML