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Cincinnati Reds vs Miami Marlins Prediction 4/22/25 MLB Picks

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Miami Marlins (9-12) vs Cincinnati Reds (11-11)

Game Info: Tuesday, April 22, 2025 at 6:40 pm (loanDepot park)

The Line: Betting Odds: Miami Marlins +105 / Cincinnati Reds -125 — Over/Under: 8.5

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The Cincinnati Reds and the Miami Marlins meet Tuesday in MLB action from LoanDepot Park. This will be the second installment in a three-game series. Here’s a Reds vs Marlins prediction. We will look at this from a betting perspective and determine the best Reds vs Marlins pick. We will examine: 

The Cincinnati Reds’ recent form and player performance

The Miami Marlins’ recent form and player performance 

Recent betting trends and streaks involving the Cincinnati Reds

Recent betting trends and streaks involving the Miami Marlins

Recent betting trends in games played between the Reds and Marlins

A summary that ties it all together and produces a favorable betting outcome for the Reds vs Marlins game

Cincinnati Reds Betting Preview

Cincinnati kicked off its season on an unfortunate skid, falling in series versus the San Francisco Giants, Texas Rangers, and Milwaukee Brewers in its first three tries. The Reds would finally get a series win in their rematch against the Giants during early April, then the team managed a sweep versus the Pittsburgh Pirates. Cincinnati would then lose two of three versus the Mariners. After a split in the first pair versus the Orioles, on Sunday, the Reds posted an insane win, 24-2, to take the set. Cincinnati got a combined 13 RBI on 11 hits from the duo of Noelvi Marte and Austin Wynns in that victory. 

In Monday’s opener versus Miami, Cincinnati gave up 10 hits in a 6-3 loss. Gavin Lux posted two of the team’s RBIs in the defeat, while starter Nick Lodolo took the loss on 5.2 innings, three earned, seven hits, and two walks. 

As a starter for Tuesday’s game, the Reds will send out Nick Martinez. This year, Martinez is 0-3 with a 6.00 ERA in four starts over 21.0 total innings. Martinez is 37-48 with a 4.14 ERA in 244 career games (107 starts). He’s also got nine saves total. 

Miami Marlins Betting Preview

Over on the Miami side, they kicked off their season on a four-game series win over four games versus the Pittsburgh Pirates, and then fell in a set versus the Mets. Miami split a pair of games versus the Braves, then fell in two of three versus the Mets, again ahead of a series win versus the Washington Nationals. Following a sweep by the Diamondbacks, Miami lost Friday 7-2 and Saturday 11-10 to the Phillies. In the Sunday finale, the Marlins scored twice in the top of the 10th inning and held on for the victory, 7-5, to stave off the sweep. Javier Sanoja did most of the offensive work with three hits, two runs, five RBI, and a homer. 

On Monday, Miami scored three runs in the seventh inning alone on the way to the win. Max Meyer lasted 6.0 innings with no earned runs on five hits as a starter. 

In the starter slot for the Marlins on Tuesday, it’ll be Edward Cabrera. So far, over two starts, Cabrera is 0-1 with a 6.52 ERA in 9.2 innings overall. Cabrera is 17-23 with a 4.39 ERA in 65 career games (63 starts) in total. 

Why the Miami Marlins will win

Why the Cincinnati Reds will win

Total Runs Facts

Reds vs Marlins Prediction 

I’ll stick with the Reds. Probably not touching this one, though. Martinez hasn’t been spectacular this season so far, going 0-3 over four starts. In his last three, Martinez is 0-2 with 10 combined earned runs across 15.0 total innings on 19 hits and six walks. Granted, Martinez should be able to handle Miami’s bats if he’s on point—but he’ll struggle if not. As for Cabrera, he’s got one good start (5.2 innings; two earned versus Washington) and one bad start (4.0 innings; five earned in a loss to the Diamondbacks) on his card so far. 

Cincinnati didn’t get the greatest pitching effort on Monday in the loss, as their first two arms gave up six earned runs over 7.0 innings between them. The Reds’ offense wasn’t good enough either, but the good news is that the hits were spread out well. Cincinnati will need some more juice from both sides on Tuesday, though. 

Andrew Jett's Pick: Cincinnati Reds -125

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