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Chicago Cubs vs Seattle Mariners Prediction 8/22/2026 Today’s MLB Picks

Aug 21, 2026; Seattle, Washington, USA; Chicago Cubs relief pitcher Colin Rea (53) throws to first base for a force out against the Seattle Mariners during the eighth inning at T-Mobile Park. Mandatory Credit: Steven Bisig-Imagn Images

Aug 21, 2026; Seattle, Washington, USA; Chicago Cubs relief pitcher Colin Rea (53) throws to first base for a force out against the Seattle Mariners during the eighth inning at T-Mobile Park. Mandatory Credit: Steven Bisig-Imagn Images

MATCHUP Chicago Cubs Seattle Mariners
Team Records 74-55 61-68
Spread -1.5 167 +1.5 -204
Moneyline +106 -114
Total Over 7.5 (-119) Under 7.5 (-101)
Where T-Mobile Park, Seattle, Washington
When Saturday, August 22, 2026
Time 07:15 PM EDT
TV MLB.TV
The Chicago Cubs and Seattle Mariners meet Saturday in MLB action at T-Mobile Park. Here’s a Chicago Cubs vs Seattle Mariners Prediction. This article will include a Chicago Cubs vs Seattle Mariners Pick.

Chicago Cubs Betting Preview


The Chicago Cubs are 74-55 on the year and play the Reds and Diamondbacks next. The Chicago Cubs are batting .248 on the season and have a .337 OBP and a .418 slugging percentage. The Chicago Cubs’ pitching staff has a 4.14 ERA and a 1.26 WHIP. Pete Crow-Armstrong leads the Chicago Cubs with 136 hits and 79 RBI, while Alex Bregman and Nico Hoerner have combined for 257 hits and 121 RBI.

David Peterson gets the ball for the Chicago Cubs, and he is 7-7 with a 5.29 ERA and 95 strikeouts this season. This will be Peterson’s second career game against the Seattle Mariners.

Seattle Mariners Betting Preview


The Seattle Mariners are 61-68 on the year and play the Phillies and Blue Jays next. The Seattle Mariners are batting .230 on the season, have a .310 OBP, and have a .375 slugging percentage. The Seattle Mariners’ pitching staff has a 4.00 ERA and a 1.23 WHIP. Josh Naylor leads the Seattle Mariners with 124 hits and 46 RBI, while Cole Young and Randy Arozarena have combined for 240 hits and 109 RBI.

Kade Anderson will make his major league debut when he takes the mound tonight. Anderson was 10-1 with a 1.06 ERA and 135 strikeouts in his minor league career. In two seasons at LSU, Anderson was 16-3 with a 3.38 ERA and 239 strikeouts.

Why the Seattle Mariners will win

Why the Chicago Cubs will win

Total Runs Facts

Seattle Mariners Player Prop Facts

Chicago Cubs Player Prop Facts

Matchup/League Facts

Chicago Cubs vs Seattle Mariners Prediction


I usually fade pitchers making their big league debut, but Peterson isn’t worth backing with this 5.29 ERA and 1.53 WHIP through 112.1 innings. Anderson also isn’t your typical prospect, as he’s considered top five in all of baseball. He dominated the College World Series, has looked sharp in the minors, and he’s expected to blossom into a front-of-the-line starter at some point. Please offer the low price and the Mariners at home.

Randy Chambers's Pick: Seattle Mariners

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