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Boston Red Sox vs Tampa Bay Rays Prediction 4/16/25 MLB Picks

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Tampa Bay Rays (8-9) vs Boston Red Sox (9-10)

Game Info: Wednesday, April 16, 2025 at 7:05 pm (George M. Steinbrenner Field)

The Line: Betting Odds: Tampa Bay Rays -148 / Boston Red Sox +124 — Over/Under: 9.5

(Get latest betting odds)

The Boston Red Sox and Tampa Bay Rays meet Wednesday in MLB action at George M. Steinbrenner Field. Here’s a Boston Red Sox vs Tampa Bay Rays Prediction. This article will include a Boston Red Sox vs Tampa Bay Rays Pick.

Boston Red Sox Betting Preview

The Boston Red Sox are 9-10 on the year and play the White Sox, Mariners, and Guardians next. The Boston Red Sox are batting .251 on the season, have a .323 OBP, and a .383 slugging percentage. The Boston Red Sox pitching staff has a 4.38 ERA and a 1.35 WHIP. Alex Bregman leads the Boston Red Sox with 25 hits and 16 RBI, while Trevor Story and Kristian Campbell have combined for 42 hits and 14 RBI. 

Sean Newcomb gets the ball for the Boston Red Sox, and he is 0-2 with a 4.97 ERA and 15 strikeouts this season. Newcomb is 1-1 with a 5.40 ERA and 13 strikeouts in his career against the Tampa Bay Rays.

Tampa Bay Rays Betting Preview

The Tampa Bay Rays are 8-9 on the year and play the Yankees, Diamondbacks, and Padres next. The Tampa Bay Rays are batting .272 on the season, have a .336 OBP, and a .429 slugging percentage. The Tampa Bay Rays pitching staff has a 3.58 ERA and a 1.13 WHIP. Jonathan Aranda leads the Tampa Bay Rays with 19 hits and 11 RBI, while Kameron Misner and Yandy Diaz have combined for 33 hits and 16 RBI.

Zack Littell gets the ball for the Tampa Bay Rays, and he is 0-3 with a 6.88 ERA and 14 strikeouts this season. Littell is 2-0 with a 2.75 ERA and 19 strikeouts in his career against the Boston Red Sox.

Why the Tampa Bay Rays will win

Why the Boston Red Sox will win

Matchup/League Facts

  • The Rays rank 3rd in the league for batting average this season (.272).
  • The Rays rank T4th in the league for strikeouts this season (165).
  • The Red Sox rank 30th in the league for runs allowed this season (97).
  • The Red Sox rank 3rd in the league for hits this season (166).

Boston Red Sox vs Tampa Bay Rays Prediction

We’ve seen double-digit run totals in the first two games of this series, and this game shouldn’t be any different. Newcomb has allowed 20 hits and seven earned runs in 12.2 innings while walking seven. Littell has allowed 18 hits and 13 runs in 17 innings. Littell has given up five homers in those frames. With the way both teams are swinging the bats and the way both pitchers have stunk up the joint, we should see another high-scoring game between the Red Sox and Rays. Give me the over.

Randy Chambers's Pick: Over 9.5

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