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Baltimore Orioles vs Washington Nationals Prediction 4/22/25 MLB Picks

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Washington Nationals (9-13) vs Baltimore Orioles (9-12)

Game Info: Tuesday, April 22, 2025 at 6:45 pm (Nationals Park)

The Line: Betting Odds: Washington Nationals +114 / Baltimore Orioles -135 — Over/Under: 9

(Get latest betting odds)

The Baltimore Orioles and the Washington Nationals meet Tuesday in MLB action from Nationals Park. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Baltimore Orioles vs. Washington Nationals prediction.

Starting Pitching Matchup

The Baltimore Orioles will send out Dean Kremer for the start here, and Kremer is 2-2 with a 6.41 ERA and 13 strikeouts this season. In his career, Kremer is 3-0 with a 2.04 ERA and 10 strikeouts against the Nationals. The Washington Nationals will start Mitchell Parker here, and Parker is 2-1 with a 1.85 ERA and 16 strikeouts this season. This will be Parker’s second career start against the Orioles.

Baltimore Orioles Recap

The Baltimore Orioles come into this game looking to bounce back from a humiliating 24-2 loss in their series rubber match against Cincinnati last time out to fall to 9-12 on the year. After this series, the Orioles will head on the road once again to take on the Detroit Tigers.

Orioles Drop Series Vs. Reds

Cedric Mullins has a team-high 19 hits so far this season as well as team-highs of 5 doubles, 6 home runs, and 19 RBIs with 3 stolen bases and a .284 batting average, while Adley Rutschman has 16 hits with a pair of doubles, 4 homers, and 7 RBIs. Ryan Mountcastle has 16 hits with 4 doubles, and Tyler O’Neill has 14 hits with 3 doubles, a triple, and 2 homers with 9 RBIs. Jordan Westburg added 4 home runs, and Gunnar Henderson has a team-high 20 strikeouts as well this season.

Why the Baltimore Orioles will win

Baltimore Orioles Player Prop Facts

Washington Nationals Recap

The Washington Nationals come into this game looking to bounce back from their 3-1 loss in the second half of Sunday’s double-header against the Colorado Rockies to fall to 9-13 this season. After this series, the Nationals will have a division series against the New York Mets at home.

Nationals Win Series Vs. Rockies After Double-Header Split

Keibert Ruiz has 22 hits with a pair of doubles and a pair of home runs with 11 RBIs, while James Wood has 19 hits with 3 doubles and a team-high 7 home runs along with 17 RBIs. Nathaniel Lowe has 23 hits with a team-high 5 doubles and 17 RBIs, along with 3 home runs and a team-high 26 strikeouts. CJ Abrams has 4 home runs and 7 RBIs along with 4 stolen bases, while Paul DeJong has 4 doubles of his own and 24 strikeouts as well this season. Dylan Crews has also logged a team-high 6 stolen bases this season.

Why the Washington Nationals will win

Washington Nationals Player Prop Facts

Total Runs Facts

Baltimore Orioles vs. Washington Nationals Prediction

I’m on the Nationals here. I get the case to be made for the Orioles, as this is still a loaded lineup. However, while I normally don’t back teams off of a Coors Field series, the Nationals had a day off to reacclimate, and I like what Mitchell Parker’s brought to the table so far this season. I haven’t been a fan of Dean Kremer so far this year, and I think that the Nationals get to him and get the win here. Give me Washington.

Chris Ruffolo's Pick: Washington Nationals +114

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