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Jacksonville Jaguars vs Indianapolis Colts Prediction 12/28/2025 Today’s NFL Picks

Indianapolis Colts wide receiver Alec Pierce (14) is tackled by acksonville Jaguars cornerback Greg Newsome II (6) during the first quarter of an NFL football game at EverBank Stadium, Sunday, Dec. 7, 2025, in Jacksonville, Fla. The Jaguars defeated the Colts 36-19.

Indianapolis Colts wide receiver Alec Pierce (14) is tackled by acksonville Jaguars cornerback Greg Newsome II (6) during the first quarter of an NFL football game at EverBank Stadium, Sunday, Dec. 7, 2025, in Jacksonville, Fla. The Jaguars defeated the Colts 36-19.

MATCHUP Jacksonville Jaguars Indianapolis Colts
Team Records 11-4 8-7
Spread -6.5 -112 +6.5 -108
Moneyline -285 +230
Total Over 48.5 (-105) Under 48.5 (-115)
Where Lucas Oil Stadium, Indianapolis, IN
When Sunday, December 28, 2025
Time 01:00 PM EST
TV FOX
In this article, we will formulate a Jaguars vs Colts Prediction for this NFL Week 17 game on Sunday, December 28th. Let’s take a look at the prediction for this NFL matchup.

Indianapolis Colts Preview


The Indianapolis Colts have an 8-6 record this season and are sitting third in the AFC South. They are 8-5-1 ATS, 7-7 in Over/Under and have a 6-1 home record and a 2-5 away record. The Colts are coming off a 16-18 away loss against the Seattle Seahawks and will face the Texans next.

Offensively, the Colts average 28 points per game, ranking 6th in the NFL, while defensively, they allow 21.6 points per game, which is 13th. Indianapolis averages 357.9 total yards per game (229 passing and 128.9 rushing), while allowing 342.7 total yards per game (95.1 rushing and 247.6 passing).

Daniel Jones leads the Colts with 3101 passing yards with 68% completed passes and 19 touchdowns. Jonathan Taylor leads the team in rushing yards with 1443, while Michael Pittman Jr. has a team-high 72 receptions for 725 receiving yards, and seven touchdowns. Defensively, Zaire Franklin has a team-high 104 total tackles (52 of them solo), while Laiatu Latu leads the team in sacks, with 6.5, while Camryn Bynum and Laiatu Latu each have 3 interceptions.

Jacksonville Jaguars Preview


The Jacksonville Jaguars have a 11-4 record this season and are sitting first in the AFC South. They are 10-4-1 ATS, 9-6 in Over/Under and have a 6-2 home record and a 5-2 away record. The Jaguars are coming off a 34-20 away win against the Denver Broncos and will face the Titans next.

Offensively, the Jaguars average 27.3 points per game, ranking 7th in the NFL, while defensively, they allow 20.8 points per game, which is 10th. Jacksonville averages 336.4 total yards per game (218.3 passing and 118.1 rushing), while allowing 317.6 total yards per game (87.3 rushing and 230.3 passing).

Trevor Lawrence leads the Jaguars with 3489 passing yards with 60% completed passes and 26 touchdowns. Travis Etienne leads the team in rushing yards with 999, while Parker Washington has a team-high 45 receptions for 645 receiving yards, and four touchdowns. Defensively, Foyesade Oluokun has a team-high 122 total tackles (61 of them solo), while Josh Hines-Allen leads the team in sacks, with 7, while Devin Lloyd has a team-high 5 interceptions.

Jacksonville Jaguars @ Indianapolis Colts Betting Trends: Week 17


Why the Indianapolis Colts will win

Why the Jacksonville Jaguars will win

Total Points Facts

Indianapolis Colts Player Prop Facts

Jacksonville Jaguars Player Prop Facts

Matchup/League Facts

Jaguars vs Colts Prediction


In this Jaguars vs Colts Prediction, the Jaguars are coming as -6.5-point road favorites. The Jaguars have a better overall record and are very strong on the road, but the Colts have been almost perfect at home this season. Both teams are coming into this matchup on opposite trajectories, as the Colts have four consecutive losses, while on the other hand, the Jags have won six straight and have covered the spread in all six. Both teams have similar numbers both offensively and defensively, but given their recent form, I have to take the Jags here as they are also 4-1 in their last 5 meetings against the Colts. Take the Jaguars and lay the -6.5 points on the road.

Nikos Lagouretos's Pick: Jacksonville Jaguars -6.5

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