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Detroit Lions vs Arizona Cardinals Prediction NFL Picks 9/22/24

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Arizona Cardinals (0-1) vs Detroit Lions (1-0)

Game Info: Sunday, September 22, 2024 at 4:25 pm (State Farm Stadium)

The Line: Betting Odds: Arizona Cardinals +3 / Detroit Lions -3 — Over/Under: 51

(Get latest betting odds)

The Detroit Lions and the Arizona Cardinals meet Sunday in NFL action from University of Phoenix Stadium. Here’s a Detroit Lions vs Arizona Cardinals prediction. We will look at this from a betting perspective and determine the best Lions vs Cardinals pick. We will examine:

The Detroit Lions’ recent form and player performance

The Arizona Cardinals’ recent form and player performance

Recent betting trends and streaks involving the Detroit Lions

Recent betting trends and streaks involving the Arizona Cardinals

Recent betting trends in games played between the Lions and Cardinals

A summary that ties it all together and produces a favorable betting outcome for the Lions vs Cardinals game

Detroit Lions Betting Preview

In Week 1 the Lions took on the Los Angeles Rams. It took overtime to get there but Detroit ultimately came away with a 26-20 victory. QB Jared Goff logged 217 yards, one TD, and one pick. David Montgomery had 91 yards and a TD rushing, while Jameson Williams caught five balls for 121 yards and a score.

In Week 2 versus the Tampa Bay Buccaneers, the Lions were down 13-6 by the end of the first half. Detroit got slightly better from there but ultimately lost 20-16. Goff had 307 yards and two interceptions this time. Amon-Ra St. Brown caught 11 balls for 119 yards to lead the receivers.

Arizona Cardinals Betting Preview

Over on the Cardinals’ side, their first action of the year came versus the Buffalo Bills. Arizona held a 17-10 lead by the break but ultimately fell 34-28 after a rough second half. QB Kyler Murray finished with 162 yards and a TD through the air while also leading the rush with 57 yards.

Facing the Los Angeles Rams in game two, the Cardinals stormed out to a 24-3 halftime edge and powered out a 41-10 victory. Murray threw for 266 yards and three touchdowns. James Conner had 122 yards and a score off 21 totes, and Marvin Harrison had four catches for 130 yards and two scores.

Total Points Facts

Arizona Cardinals Player Prop Facts

Detroit Lions Player Prop Facts

Detroit Lions vs Arizona Cardinals Prediction

I’m going with Arizona. Outside of a lost fumble, the Cardinals’ offense was cooking in their last matchup with the Rams. Arizona bagged 489 yards (231 rushing), 7.9 yards per play, 24 first downs, and a 7-of-11 rate on third-down tries. Defensively the Cards held LA to just 245 yards (192 passing) and 2-of-11 on thirds in a dominant display.

As for Detroit, they posted 463 yards (324 passing) and 26 first downs against Tampa Bay. The defensive statistics were good as well: 216 yards (146 passing) and 14 first downs allowed alongside 2-of-10 in third-down efficiency. The Lions still found a way to lose, however. Specifically, Goff wasn’t at his best. I like Detroit to bounce back and give Arizona a game Sunday but I don’t quite think they’ll cover.

Andrew Jett's Pick: Arizona Cardinals +3

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