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Buffalo Bills vs New England Patriots Prediction 12/14/2025 Today’s NFL Picks

Dec 1, 2025; Foxborough, Massachusetts, USA; New England Patriots running back TreVeyon Henderson (32) runs the ball during the second quarter against the New York Giants at Gillette Stadium. Mandatory Credit: Eric Canha-Imagn Images

Dec 1, 2025; Foxborough, Massachusetts, USA; New England Patriots running back TreVeyon Henderson (32) runs the ball during the second quarter against the New York Giants at Gillette Stadium. Mandatory Credit: Eric Canha-Imagn Images

MATCHUP Buffalo Bills New England Patriots
Team Records 9-4 11-2
Spread -1.5 -102 +1.5 -118
Moneyline -120 +100
Total Over 49.5 (-108) Under 49.5 (-112)
Where Gillette Stadium, Foxborough, MA
When Sunday, December 14, 2025
Time 01:00 PM EST
TV CBS
The Buffalo Bills and New England Patriots meet Sunday in NFL action at Gillette Stadium. Here’s a Buffalo Bills vs New England Patriots Prediction. This article will include a Buffalo Bills vs New England Patriots Pick.

Buffalo Bills Betting Preview


The Buffalo Bills beat the Steelers and Bengals, and they play the Browns next. The Bills have won 5 of their last 7 games. Josh Allen is completing 70.1 percent of his passes for 3,083 yards, 22 touchdowns, and 10 interceptions. Khalil Shakir and Dalton Kincaid have combined for 1,074 receiving yards and 9 touchdowns, while Keon Coleman has 36 receptions.

The Buffalo Bills ground game is averaging 157.8 yards per contest, and James Cook leads the way with 1,308 yards and 8 touchdowns. Defensively, Buffalo is allowing 22.5 points and 307.1 yards per game. Cole Bishop leads the Buffalo Bills with 71 tackles, Joey Bosa has 5 sacks and Maxwell Hairston has 2 interceptions.

New England Patriots Betting Preview


The New England Patriots beat the Bengals and Giants, and play the Ravens next. The New England Patriots have won 10 straight games. Drake Maye is completing 71.5 percent of his passes for 3,412 yards, 23 touchdowns, and 6 interceptions. Stefon Diggs and Hunter Henry have combined for 1,315 receiving yards and 8 touchdowns, while Kayshon Boutte has 29 receptions.

The New England Patriots ground game is averaging 112.9 yards per contest, and TreVeyon Henderson leads the way with 625 yards and 5 touchdowns. Defensively, New England is allowing 18.5 points and 296.4 yards per game. Robert Spillane leads the New England Patriots with 97 tackles, Harold Landry III has 7.5 sacks and Marcus Jones has 3 interceptions.

Why the New England Patriots will win

Why the Buffalo Bills will win

Total Points Facts

New England Patriots Player Prop Facts

Buffalo Bills Player Prop Facts

Matchup/League Facts

Buffalo Bills vs New England Patriots Prediction


You can make a strong case for the Bills, as they’re in must-win territory and Josh Allen is one of those guys capable of putting the team on his back and just finding a way. However, the Patriots haven’t lost a game since week 3, and they’re at home with the rest advantage. i love my dogs that have had extra time to prepare. I understand the Pats have won 10 straight games, covered 7 of those games, and you’re just waiting for a slip-up. It can happen. I’m just not turning down free points with a team that keeps winning and has proven to be legit with a top-10 scoring offense and scoring defense. The underdog has covered 7 of the last 10 games between the Patriots and Bills. I’m going to take the points with the Patriots at home.

Randy Chambers's Pick: New England +1.5

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