| MATCHUP | Arizona Cardinals | San Francisco 49ers |
|---|---|---|
| Team Records | 1-1 | 2-0 |
| Spread | +8.5 -112 | -8.5 -108 |
| Moneyline | +350 | -455 |
| Total | Over 47.5 (-115) | Under 47.5 (-105) |
| Where | Levi's Stadium, Santa Clara, CA | |
| When | Sunday, September 27, 2026 | |
| Time | 04:05 PM EDT | |
| TV | FOX | |
Arizona Cardinals Betting Preview
The Arizona Cardinals beat the Chargers, lost to the Seahawks, and play the Giants next. The Arizona Cardinals have lost 10 of their last 11 games. Jacoby Brissett is completing 67.7 percent of his passes for 372 yards, 2 touchdowns, and 1 interception. Trey McBride and Kendrick Bourne have combined for 222 receiving yards and 2 touchdowns, while Michael Wilson has 7 receptions.
The Arizona Cardinals’ ground game is averaging 93 yards per contest, and Tyler Allgeier leads the way with 71 yards on 22 carries. Defensively, Arizona is allowing 22.5 points and 324.5 yards per game. Jack Gibbens Sr. leads the Arizona Cardinals with 16 tackles, Budda Baker has 1.5 sacks, and Andrew Wingard has 1 interception.
San Francisco 49ers Betting Preview
The San Francisco 49ers beat the Rams and Dolphins, and play the Broncos next. The San Francisco 49ers look for their third 3-0 start in the last four years. Brock Purdy is completing 80.4 percent of his passes for 492 yards, 5 touchdowns, and 1 interception. Mike Evans and George Kittle have combined for 195 receiving yards and 2 touchdowns, while Demarcus Robinson has 5 receptions.
The San Francisco 49ers ground game is averaging 134.5 yards per contest, and Christian McCaffrey leads the way with 91 yards and 2 touchdowns. Defensively, San Francisco is allowing 10 points and 287 yards per game. Ji’Ayir Brown leads the San Francisco 49ers with 18 tackles, Marques Sigle has 1 sack, and Renardo Green has 1 interception.
Why the San Francisco 49ers will win
- The Cardinals have lost each of their last 12 Sunday games against opponents on a winning streak.
- The 49ers have won each of their last eight Sunday games against starting rookie QBs.
- The Cardinals have failed to cover the spread in each of their last six games as underdogs against NFC West opponents.
- The 49ers have covered the spread in seven of their last eight games as favorites against starting rookie QBs.
- The Cardinals have lost the first quarter in six of their last eight September games against NFC West opponents.
- The Cardinals have lost the first half in each of their last seven road games against teams that held a winning record.
Why the Arizona Cardinals will win
- The 49ers have lost each of their last three games as favorites without Deebo Samuel.
- The Cardinals have won each of their last four games at Levi’s Stadium following a Division game.
- The Cardinals have covered the spread in each of their last eight September games as road underdogs.
- The 49ers have failed to cover the spread in each of their last six games as home favorites against NFC West opponents.
Total Points Facts
- Eleven of the Cardinals’ last 12 road games in September have gone UNDER the total points line.
- Each of the 49ers’ last five Sunday games played on the West Coast have gone OVER the total points line.
- Four of the last five Sunday games at Levi’s Stadium have gone OVER the total points line.
San Francisco 49ers Player Prop Facts
- Deebo Samuel has scored the last touchdown in six of his last seven September appearances against NFC opponents.
- Deebo Samuel has scored a touchdown in each of his last four September appearances against NFC opponents.
- Brock Purdy has recorded 21+ rushing yards in seven of the 49ers’ last eight games.
- Brock Purdy has recorded 22+ completions in each of his last four September appearances with the 49ers as favorites against NFC opponents.
- Brock Purdy has recorded 244+ passing yards in 11 of the 49ers’ last 12 home games as heavy favorites (>-7.0 points).
- George Kittle has recorded 61+ receiving yards in each of his last eight appearances with the 49ers as home favorites.
- Deebo Samuel has recorded 52+ rushing and receiving yards in each of his eight previous September appearances with the 49ers as favorites against NFC opponents.
- Heading into Week 3, Brock Purdy has the most games with a 100+ passer rating this season (2).
Arizona Cardinals Player Prop Facts
- Trey McBride has scored the last touchdown in three of the Cardinals’ last four games as underdogs in California.
- Trey McBride has scored at least one touchdown in nine of the Cardinals’ last 10 games as road underdogs.
- Kendrick Bourne has recorded 22+ receiving yards in each of his seven previous Week 3 appearances.
- James Conner has recorded 55+ rushing yards in 11 of his last 13 appearances following a home loss.
- Kendrick Bourne has recorded 22+ rushing and receiving yards in each of his seven previous Week 3 appearances.
- Heading into Week 3, Tyler Allgeier ranks T1st amongst qualified players for catch rate (100.0%) this season.
Matchup/League Facts
- Heading into Week 3, the 49ers rank 1st in the NFL in Q3 points per game (14.0) this season.
- Heading into Week 3, the 49ers rank T1st in the NFL in Q1 win percentage (100.0) this season.
- Heading into Week 3, the Cardinals rank 1st in the NFL in average points against in second quarters this season (0.0).
- Cardinals – one different rookies have recorded at least one touchdown this season – equal-most in the NFL, heading into Week 3.
Arizona Cardinals vs San Francisco 49ers Prediction
I’m still trying to figure out if the Cardinals are decent or not, as they turned heads against the Chargers but laid an egg against the Seahawks. The 49ers are 2-0 SU and ATS, and they look in fantastic form on both sides of the ball despite the injuries piling up. It’s a tough number, but I need to see more from the Cardinals before I can back them against the best teams in the league. I’ll lean toward the 49ers in this spot.