Yankees vs Red Sox Prediction 4/22/2026 Today’s MLB Picks

In this article we will formulate a Yankees vs Red Sox prediction for this MLB game on Wednesday, April 22nd at Fenway Park in Boston, Massachusetts. Let’s take a look at the prediction for this MLB matchup. 

New York Yankees Betting Preview

The New York Yankees are 14-9 this season after they won game one by a score of 4-0 on Tuesday night. New York jumped out to a 1-0 lead in the second inning and they never looked back in the shutout win. The Yankees recorded 10 hits in the game and they were led by Stanton, who went 2-4 with one home run and three RBIs. Gil allowed two hits and zero earned runs over 6.1 innings for the win, while Headrick picked up a hold. Prior to this series, New York swept the Royals in three games and split four games with the Angels. 

This season, New York has a 3.25 ERA with a 1.15 WHIP and a .225 opponent batting average, while they have scored 114 runs with a .222 batting average and a .326 on base percentage. Aaron Judge has led the Yankees with nine home runs and 16 RBIs, while Ben Rice has added eight home runs and 18 RBIs. The projected starting pitcher for New York is Max Fried, who is 2-1 with a 2.97 ERA and a 0.81 WHIP over 33.1 innings pitched this season. 

Boston Red Sox Betting Preview

The Boston Red Sox are 9-14 this year after they lost game one by a score of 4-0 last night. Boston struggled at the plate all night and never found any offense in the shutout loss. The Red Sox recorded four hits in the game and they were led by Narvaez, who went 1-3. Early allowed five hits and three earned runs over 5.1 innings for the loss, while Anderson allowed one earned run in relief. Prior to this series, Boston split four games with the Tigers and lost two out of three against the Twins before that. 

This season, Boston has a 4.40 ERA with a 1.34 WHIP and a .243 opponent batting average, while they have scored 89 runs with a .229 batting average and a .314 on base percentage. Wilson Contreras has led the Red Sox with four home runs and 12 RBIs, while Trevor Story has added two home runs and 17 RBIs. The projected starting pitcher for Boston is Ranger Suarez, who is 1-1 with a 3.22 ERA and a 1.07 WHIP over 22.1 innings pitched this year. 

Why the Boston Red Sox will win

• The Yankees have lost each of their last four games as road favorites against AL East opponents.
• The Red Sox have won four of their last six games as underdogs following a home loss.
• The Yankees have failed to cover the run line in each of their last seven Wednesday night games as favorites against AL East opponents.
• The underdogs have covered the run line in 10 of the Yankees’ last 13 games.

Why the New York Yankees will win

• The Yankees have won each of their last 11 Wednesday night games against the Red Sox.
• The Red Sox have lost each of their last six games as underdogs after playing the previous day.
• The Red Sox have failed to cover the run line each of their last six night games against American League opponents that held a winning record.
• The Yankees have covered the run line each of their last four games against teams that held a losing record.
• The Red Sox have trailed after 3 innings in four of their last five games as home underdogs against American League opponents.
• The Yankees have led after 5 innings in each of their last five games.

Total Runs Facts

• Each of the Red Sox’s last five games as underdogs against the Yankees have gone UNDER the total runs line.
• Each of the Yankees’ last four night games against American League opponents have gone UNDER the total runs line.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Red Sox’s last nine Wednesday night games against American League opponents.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in 13 of the Yankees’ last 15 night games at Fenway Park.

Boston Red Sox Player Prop Facts

• Ranger Suarez has recorded six or more strikeouts in each of his last five appearances against AL East opponents that held a winning record.
• Ranger Suarez has recorded a win in three of his last four appearances with his team as a home underdog .
• Triston Casas has hit a home run in each of his last two appearances in night games against teams that held a winning record.
• Jarren Duran has recorded at least one hit in each of the Red Sox’s last 19 Wednesday night games at Fenway Park.

New York Yankees Player Prop Facts

• Aaron Judge has hit at least one home run in five of the Yankees’ last eight games as favorites against AL opponents.
• Cody Bellinger has recorded at least one hit in each of his last nine appearances against AL opponents.
• Max Fried has recorded a win in four of his five previous road appearances against AL East opponents that held a losing record.

Yankees vs Red Sox Prediction 

New York was able to start this rivalry series with a win on Tuesday night and they have won four games in a row. The Yankees are 6-4 on the road this year, while the Red Sox are 5-6 at home. Boston has lost three of their last four games and they have scored two runs or fewer in four of their last five. The Red Sox are starting Suarez, who has allowed zero earned runs in his last two starts, while Fried has allowed 11 earned runs and 14 hits in his last 20.0 innings. We have seen some struggles from Fried recently, so I like the Red Sox at home in this one.

David Racey's Pick: Red Sox ML