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Washington Nationals vs St. Louis Cardinals Prediction 9/18/2026 Today’s MLB Picks

Sep 16, 2026; Washington, District of Columbia, USA; Washington Nationals second baseman Nasim Nuñez (26) reaches to catch a pop up by Philadelphia Phillies shortstop Trea Turner (not pictured) during the seventh inning at Nationals Park. Mandatory Credit: Geoff Burke-Imagn Images

Sep 16, 2026; Washington, District of Columbia, USA; Washington Nationals second baseman Nasim Nuñez (26) reaches to catch a pop up by Philadelphia Phillies shortstop Trea Turner (not pictured) during the seventh inning at Nationals Park. Mandatory Credit: Geoff Burke-Imagn Images

MATCHUP Washington Nationals St. Louis Cardinals
Team Records 71-82 75-78
Spread -1.5 160 +1.5 -195
Moneyline -105 -115
Total Over 7.5 (-116) Under 7.5 (-104)
Where Busch Stadium, St. Louis, Missouri
When Friday, September 18, 2026
Time 08:15 PM EDT
TV MLB.TV
The Washington Nationals and St. Louis Cardinals meet Friday in MLB action at Busch Stadium. Here’s a Washington Nationals vs. St. Louis Cardinals Prediction. This article will include a Washington Nationals vs. St. Louis Cardinals Pick.

Washington Nationals Betting Preview 


The Washington Nationals are 71-82 on the year and play the Tigers and Mets next. The Washington Nationals are batting .247 on the season and have a .323 OBP and a .426 slugging percentage. The Washington Nationals’ pitching staff has a 4.71 ERA and a 1.39 WHIP. CJ Abrams leads the Washington Nationals with 144 hits and 96 RBI, while James Wood and Daylen Lile have combined for 270 hits and 160 RBI.

Cade Cavalli gets the ball for the Washington Nationals, and he is 12-5 with a 3.12 ERA and 194 strikeouts this season. This will be Cavalli’s second career game against the St. Louis Cardinals.

St. Louis Cardinals Betting Preview 


The St. Louis Cardinals are 75-78 this year and play the Brewers and Pirates next. The St. Louis Cardinals are batting .242 on the season, with a .316 OBP and a .382 slugging percentage. The St. Louis Cardinals’ pitching staff has a 4.28 ERA and a 1.36 WHIP. Alec Burleson leads the St. Louis Cardinals with 164 hits and 111 RBI, while Jordan Walker and Ivan Herrera have combined for 298 hits and 165 RBI.

Kyle Leahy gets the ball for the St. Louis Cardinals, and he is 10-4 with a 3.33 ERA and 128 strikeouts this season. Leahy is 0-0 with a 7.71 ERA and 1 strikeout in his career against the Washington Nationals.

Why the St. Louis Cardinals will win

Why the Washington Nationals will win

Total Runs Facts

St. Louis Cardinals Player Prop Facts

Washington Nationals Player Prop Facts

Matchup/League Facts

Washington Nationals vs St. Louis Cardinals Prediction


Neither team has anything to play for heading into the last week of the season, but the Nationals continue to play hard and have cashed us some nice tickets. Cavalli has been a bright spot for the Nats with a 3.12 ERA and 1.117 WHIP, and he’s allowed 7 hits and 4 runs in his last 16 innings. We’re getting the slightly more favorable price with the Nationals. I’ll take it.

Randy Chambers's Pick: Washington Nationals

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