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Tampa Bay Rays vs Chicago White Sox Prediction 4/16/2026 Today’s MLB Picks

Mar 29, 2026; St. Louis, Missouri, USA; Tampa Bay Rays starting pitcher Steven Matz (32) pitches against the St. Louis Cardinals during the first inning at Busch Stadium. Mandatory Credit: Jeff Curry-Imagn Images

Mar 29, 2026; St. Louis, Missouri, USA; Tampa Bay Rays starting pitcher Steven Matz (32) pitches against the St. Louis Cardinals during the first inning at Busch Stadium. Mandatory Credit: Jeff Curry-Imagn Images

MATCHUP Tampa Bay Rays Chicago White Sox
Team Records 10-7 6-12
Where Rate Field, Chicago, Illinois
When Thursday, April 16, 2026
Time 02:10 PM EDT
TV MLB.TV

In this article, we will formulate a Rays vs White Sox Prediction for this MLB matchup on Thursday, April 16th in the third game of this series. Let’s take a look at the prediction for this MLB matchup.

Chicago White Sox Preview

The Chicago White Sox have a 6-12 record this season and are sitting in the fifth place of the AL Central. They have a 3-5 home record and are coming off a 3-8 home loss against the Rays. Their previous three games were a 5-8 home loss against the Rays, a 6-5 road win, and a 0-2 road loss against the Royals.

The White Sox have a .193 batting average this season, .284 OBP and .306 Slugging percentage. Chicago’s pitching staff has a 5.02 ERA and 1.46 WHIP. Chase Meidroth is the team’s best hitter with a .203 batting average. Munetaka Murakami leads the team in RBI with 9, also adding a team‑high 5 home runs.

Anthony Kay (L) is the projected starting pitcher for the White Sox, and he has a 1-0 record, 2.45 ERA and 1.16 WHIP.

Tampa Bay Rays Preview

The Tampa Bay Rays have a 10-7 record this season and are sitting in the first place of the AL East. They have a 6-5 away record and are coming off an 8-3 road win against the White Sox. Their previous three games were an 8-5 road win against the White Sox, and a 5-4 and a 5-4 home win against the Yankees.

The Rays have a .266 batting average this season, .337 OBP and .399 Slugging percentage. Tampa Bay’s pitching staff has a 4.46 ERA and 1.24 WHIP. Chandler Simpson is the team’s best hitter with a .381 batting average. Yandy Diaz leads the team in RBI with 16, also adding a team‑high 3 home runs.

Steven Matz (L) is the projected starting pitcher for the Rays, and he has a 3-0 record, 3.94 ERA and 0.94 WHIP.

Tampa Bay Rays @ the Chicago White Sox Betting Trends: April 16, 2026

Why the Chicago White Sox will win

Why the Tampa Bay Rays will win

Total Runs Facts

Chicago White Sox Player Prop Facts

Tampa Bay Rays Player Prop Facts

Matchup/League Facts

Rays vs White Sox Prediction

Both teams are tied 5-5 in their last 10 meetings and are 2-2 in their last 4 meetings in Chicago.

In this Rays vs White Sox Prediction, the Rays are coming as -130 road favorites. The Rays have won both games of this series having scored 8 runs in each one and there is no reason to not keep backing them up with Matz on the mound. He has a mediocre ERA but a sub-one WHIP and the Rays’ bullpen is no longer the worst in baseball. They also have a superior offense, scoring almost two runs per game more than the White Sox, who have a measly .192 batting average this season. Take the Rays to win this one on the road.

Nikos Lagouretos's Pick: Tampa Bay Rays ML

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