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St. Louis Cardinals vs Washington Nationals Prediction 5/11/25 MLB Picks

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Washington Nationals (17-23) vs St. Louis Cardinals (21-19)

Game Info: Sunday, May 11, 2025 at 1:35 pm (Nationals Park)

The Line: Betting Odds: Washington Nationals -135 / St. Louis Cardinals +114 — Over/Under: 8.5

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The St. Louis Cardinals and Washington Nationals meet Sunday in MLB action at Nationals Park. Here’s a St. Louis Cardinals vs Washington Nationals Prediction. This article will include a St. Louis Cardinals vs Washington Nationals Pick.

St. Louis Cardinals Betting Preview

The St. Louis Cardinals are 21-19 on the year and play the Phillies, Royals, and Tigers next. The St. Louis Cardinals are batting .261 on the season, have a .337 OBP, and a .399 slugging percentage. The St. Louis Cardinals’ pitching staff has a 3.92 ERA and a 1.24 WHIP. Brendan Donovan leads the St. Louis Cardinals with 48 hits and 19 RBI, while Lars Nootbaar and Willson Contreras have combined for 73 hits and 43 RBI. 

Miles Mikolas gets the ball for the St. Louis Cardinals, and he is 1-2 with a 4.76 ERA and 18 strikeouts this season. Mikolas is 4-3 with a 3.42 ERA and 29 strikeouts in his career against the Washington Nationals.

Washington Nationals Betting Preview

The Washington Nationals are 17-23 on the year and play the Braves, Orioles, and Braves next. The Washington Nationals are batting .240 on the season, have a .310 OBP, and a .381 slugging percentage. The Washington Nationals’ pitching staff has a 5.43 ERA and a 1.46 WHIP. James Wood leads the Washington Nationals with 43 hits and 23 RBI, while Keibert Ruiz and Nathaniel Lowe have combined for 74 hits and 42 RBI.

MacKenzie Gore gets the ball for the Washington Nationals, and he is 2-3 with a 3.33 ERA and 68 strikeouts this season. Gore is 0-1 with a 10.05 ERA and 16 strikeouts in his career against the St. Louis Cardinals.

Why the Washington Nationals will win

Why the St. Louis Cardinals will win

Washington Nationals Player Prop Facts

St. Louis Cardinals Player Prop Facts

St. Louis Cardinals vs Washington Nationals Prediction

You can make a case for the Nationals, as Gore has been solid this season with a top-40 ERA and WHIP, and he leads baseball in strikeouts. The problem is that the Nats have scored two or fewer runs in three of their last four games. 

The Cardinals have won seven straight games, and they’re rolling with their lineup and pitching staff. The Cardinals have allowed a combined two runs in their last three games. Mikolas has allowed a combined 13 hits and three runs in his last 16.1 innings, easily his best stretch of the season. Also, Gore is allowing a .463 batting average and a .500 on-base percentage in 41 at-bats against current Cardinals’ hitters. I’m just not trying to step in front of the Cardinals in their current form. I’m not sure how the Cardinals are underdogs in this spot. I’ll gladly take the plus money and the hottest team in baseball.

Randy Chambers's Pick: St. Louis Cardinals +114

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