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St. Louis Cardinals vs Philadelphia Phillies Prediction 8/22/2026 Today’s MLB Picks

Aug 21, 2026; Philadelphia, Pennsylvania, USA; Philadelphia Phillies second baseman Luis Arraez (4) reacts after hitting a single during the tenth inning against the St. Louis Cardinals at Citizens Bank Park. Mandatory Credit: Bill Streicher-Imagn Images

Aug 21, 2026; Philadelphia, Pennsylvania, USA; Philadelphia Phillies second baseman Luis Arraez (4) reacts after hitting a single during the tenth inning against the St. Louis Cardinals at Citizens Bank Park. Mandatory Credit: Bill Streicher-Imagn Images

MATCHUP St. Louis Cardinals Philadelphia Phillies
Team Records 66-64 71-58
Spread +1.5 -198 -1.5 162
Moneyline +120 -129
Total Over 9 (-105) Under 9 (-115)
Where Citizens Bank Park, Philadelphia, Pennsylvania
When Saturday, August 22, 2026
Time 06:05 PM EDT
TV MLB.TV
The St. Louis Cardinals and Philadelphia Phillies meet Saturday in MLB action at Citizens Bank Park. Here’s a St. Louis Cardinals vs Philadelphia Phillies Prediction. This article will include a St. Louis Cardinals vs Philadelphia Phillies Pick.

St. Louis Cardinals Betting Preview


The St. Louis Cardinals are 66-64 on the year and play the Pirates and Orioles next. The St. Louis Cardinals are batting .240 on the season, with a .316 OBP and a .382 slugging percentage. The St. Louis Cardinals’ pitching staff has a 4.04 ERA and a 1.34 WHIP. Alec Burleson leads the St. Louis Cardinals with 135 hits and 90 RBI, while Jordan Walker and Ivan Herrera have combined for 247 hits and 140 RBI.

Andre Pallante gets the ball for the St. Louis Cardinals, and he is 12-6 with a 3.57 ERA and 97 strikeouts this season. Pallante is 1-1 with a 3.18 ERA and 11 strikeouts in his career against the Philadelphia Phillies.

Philadelphia Phillies Betting Preview


The Philadelphia Phillies are 71-58 on the year and play the Mariners and Angels next. The Philadelphia Phillies are batting .240 on the season, with a .311 OBP and a .401 slugging percentage. The Philadelphia Phillies’ pitching staff has a 4.16 ERA and a 1.31 WHIP. Trea Turner leads the Philadelphia Phillies with 123 hits and 48 RBI, while Bryce Harper and Brandon Marsh have combined for 234 hits and 126 RBI.

Andrew Painter gets the ball for the Philadelphia Phillies, and he is 2-8 with a 6.43 ERA and 71 strikeouts this season. This will be Painter’s second career game against the St. Louis Cardinals.

Why the Philadelphia Phillies will win

Why the St. Louis Cardinals will win

Total Runs Facts

Philadelphia Phillies Player Prop Facts

St. Louis Cardinals Player Prop Facts

Matchup/League Facts

St. Louis Cardinals vs Philadelphia Phillies Prediction


The Cardinals are fighting for a playoff spot and need to pile up the wins to keep pace. While the Phillies are the better team overall, Painter has a 6.43 ERA and 1.55 WHIP through 85.1 innings. No thanks. Pallante is far more trustworthy with a 3.57 ERA and 1.24 WHIP through 136 innings. The Cardinals and the plus-money have to be among the better value bets on Saturday.

Randy Chambers's Pick: St. Louis Cardinals

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