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St. Louis Cardinals vs Milwaukee Brewers Prediction 5/27/2026 Today’s MLB Picks

May 9, 2026; San Diego, California, USA; St. Louis Cardinals starting pitcher Dustin May (3) throws a pitch during the sixth inning against the San Diego Padres at Petco Park. Mandatory Credit: David Frerker-Imagn Images

May 9, 2026; San Diego, California, USA; St. Louis Cardinals starting pitcher Dustin May (3) throws a pitch during the sixth inning against the San Diego Padres at Petco Park. Mandatory Credit: David Frerker-Imagn Images

MATCHUP St. Louis Cardinals Milwaukee Brewers
Team Records 29-24 32-20
Spread +1.5 -168 -1.5 139
Moneyline +128 -155
Total Over 8.5 (-102) Under 8.5 (-118)
Where American Family Field, Milwaukee, Wisconsin
When Wednesday, May 27, 2026
Time 01:40 PM EDT
TV MLB.TV
In this article, we will formulate a Cardinals vs Brewers Prediction for this MLB matchup on Wednesday, May 27th in the third game of this series. Let’s take a look at the prediction for this MLB matchup.

Milwaukee Brewers Preview


The Milwaukee Brewers have a 32-20 record this season and are sitting in the first place of the NL Central. They have a 18-11 home record and are coming off a 6-0 home win against the Cardinals. They will face the Astros and the Giants next.

The Brewers have a .249 batting average this season, .335 OBP and .368 Slugging percentage. Milwaukee’s pitching staff has a 3.19 ERA and 1.19 WHIP. William Contreras is the team’s best hitter with a .308 batting average, also leading the team in RBI with 33. Jake Bauers adds a team-high 8 home runs.

The Brewers have not yet announced a starting pitcher for this game.

St. Louis Cardinals Preview


The St. Louis Cardinals have a 29-24 record this season and are sitting in the second place of the NL Central. They have a 16-11 away record and are coming off a 0-6 road defeat against the Brewers. They will face the Cubs and the Rangers next.

The Cardinals have a .238 batting average this season, .318 OBP and .384 Slugging percentage. St. Louis’ pitching staff has a 4.27 ERA and 1.39 WHIP. Jordan Walker is the team’s best hitter with a .296 batting average, also leading the team in RBI with 42 and adding a team-high 15 home runs.

Dustin May (R) is the projected starting pitcher for the Cardinals, and he has a 3-5 record, 5.00 ERA and 1.43 WHIP.

St. Louis Cardinals @ Milwaukee Brewers Betting Trends: May 27, 2026


Why the Milwaukee Brewers will win


Why the St. Louis Cardinals will win

Total Runs Facts

Milwaukee Brewers Player Prop Facts

St. Louis Cardinals Player Prop Facts

Matchup/League Facts

Cardinals vs Brewers Prediction


The Brewers have won their last three meetings against the Cardinals and are 4-1 in their last 5 meetings in Milwaukee.  

In this Cardinals vs Brewers Prediction, the Brewers are coming as -150 home favorites. Even without a pitcher announced, you just have to ride with the Brewers in this one. They have dominated both games in this series with a combined 11-1 score and Dustin May has been terrible for the Cardinals and even weaker on the road. The Brewers have both a better offense and a better bullpen and I expect them to keep rolling and sweep the Cardinals in this series.

Nikos Lagouretos's Pick: Milwaukee Brewers ML

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