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St. Louis Cardinals vs Detroit Tigers Prediction 4/4/2026 Today’s MLB Picks

Detroit Tigers pitcher Jack Flaherty (9) throws against Seattle Mariners during the second inning during ALDS Game 3 at Comerica Park in Detroit on Tuesday, Oct. 7, 2025.

Detroit Tigers pitcher Jack Flaherty (9) throws against Seattle Mariners during the second inning during ALDS Game 3 at Comerica Park in Detroit on Tuesday, Oct. 7, 2025.

MATCHUP St. Louis Cardinals Detroit Tigers
Team Records 4-3 3-4
Where Comerica Park, Detroit, Michigan
When Saturday, April 4, 2026
Time 01:10 PM EDT
TV ESPN Unlmtd

In this article, we will formulate a Cardinals vs Tigers Prediction for this MLB matchup on Saturday, April 4th in the second game of this series. Let’s take a look at the prediction for this MLB matchup.

Detroit Tigers Preview

The Detroit Tigers have a 3-4 record this season and are sitting in the fourth place of the AL Central. They have a 1-0 home record and are coming off a 4-0 home win over the Cardinals. Their previous three games were a 0-1, 5-7 and a 6-9 road loss to the Diamondbacks.

The Tigers have a .228 batting average this season, .306 OBP and .323 Slugging percentage. Detroit’s pitching staff has a 3.20 ERA and 1.25 WHIP. Colt Keith is the team’s best hitter with a .364 batting average. Dillon Dingler leads the team in RBI with 7, also adding a team-high two home runs.

Jack Flaherty (R) is the projected starting pitcher for the Tigers, and he has a 0-1 record, 4.15 ERA and 1.85 WHIP.

St. Louis Cardinals Preview

The St. Louis Cardinals have a 4-3 record this season and are sitting in the second place of the NL Central. They have a 0-1 road record and are coming off a 0-4 road loss to the Tigers. Their previous three games were a 2-1 home win, a 3-0 home win and a 2-4 home loss to the Mets.

The Cardinals have a .220 batting average this season, .278 OBP and .347 Slugging percentage. St. Louis’ pitching staff has a 4.29 ERA and 1.49 WHIP. Victor Scott II is the team’s best hitter with a .333 batting average. Nolan Gorman leads the team in RBI with 6, also adding a team-high two home runs.

Dustin May (R) is the projected starting pitcher for the Cardinals, and he has a 0-1 record, 13.50 ERA and 2.75 WHIP.

St. Louis Cardinals @ Detroit Tigers Betting Trends: April 4, 2026

Why the Detroit Tigers will win

Why the St. Louis Cardinals will win

Total Runs Facts

Detroit Tigers Player Prop Facts

St. Louis Cardinals Player Prop Facts

Matchup/League Facts

Cardinals vs Tigers Prediction

The Tigers are 5-1 in their last 6 meetings against the Cardinals, having won their last three meetings in Detroit.  

In this Cardinals vs Tigers Prediction, the Tigers are coming as -160 home favorites. The Tigers shut out the Cardinals yesterday with a 4-0 score and are putting Flaherty on the mound today who has been historically better at home. On the flip side, Dustin May takes the mound for the Cardinals and he was torched in his first start of the season by the Rays with 6 earned runs and has been playing historically worse on the road. On top of that, the Cardinals have been weaker against right-handed pitching this season, so give me the Tigers on the moneyline in this one.

Nikos Lagouretos's Pick: Detroit Tigers ML

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