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St. Louis Cardinals vs Cincinnati Reds Prediction 5/23/2026 Today’s MLB Picks

Mar 31, 2026; St. Louis, Missouri, USA; St. Louis Cardinals starting pitcher Andre Pallante (53) pitches against New York Mets second baseman Marcus Semien (10) during the fourth inning at Busch Stadium. Mandatory Credit: Jeff Curry-Imagn Images

Mar 31, 2026; St. Louis, Missouri, USA; St. Louis Cardinals starting pitcher Andre Pallante (53) pitches against New York Mets second baseman Marcus Semien (10) during the fourth inning at Busch Stadium. Mandatory Credit: Jeff Curry-Imagn Images

MATCHUP St. Louis Cardinals Cincinnati Reds
Team Records 28-21 26-24
Spread -1.5 143 +1.5 -174
Moneyline -112 -108
Total Over 9.5 (-111) Under 9.5 (-108)
Where Great American Ball Park, Cincinnati, Ohio
When Saturday, May 23, 2026
Time 01:10 PM EDT
TV MLB.TV
In this article, we will formulate a Cardinals vs Reds Prediction for this MLB matchup on Saturday, May 23rd in the opening game of this series. Let’s take a look at the prediction for this MLB matchup.

Cincinnati Reds Preview


The Cincinnati Reds have a 26-24 record this season and are sitting in the fourth place of the NL Central. They have a 13-11 home record and are coming off a 9-4 home win against the Phillies. They will face the Mets and the Braves next.

The Reds have a .229 batting average this season, .312 OBP and .394 Slugging percentage. Cincinnati’s pitching staff has a 4.71 ERA and 1.46 WHIP. Elly De La Cruz is the team’s best hitter with a .290 batting average. Sal Stewart leads the team in RBI with 34, adding a team-high 12 home runs.

Chris Paddack (R) is the projected starting pitcher for the Reds, and he has a 0-5 record, 7.07 ERA and 1.63 WHIP.

St. Louis Cardinals Preview


The St. Louis Cardinals have a 28-21 record this season and are sitting in the second place of the NL Central. They have a 15-8 away record and are coming off a 6-2 road loss against the Pirates. They will face the Brewers and the Cubs next.

The Cardinals have a .240 batting average this season, .320 OBP and .389 Slugging percentage. St. Louis’ pitching staff has a 4.24 ERA and 1.38 WHIP. Jordan Walker is the team’s best hitter with a .295 batting average, also leading the team in RBI with 35 and adding a team-high 13 home runs.

Andre Pallante (R) is the projected starting pitcher for the Cardinals, and he has a 4-4 record, 4.04 ERA and 1.35 WHIP.

St. Louis Cardinals @ Cincinnati Reds Betting Trends: May 23, 2026: Game 1


Why the Cincinnati Reds will win


Why the St. Louis Cardinals will win

Total Runs Facts

Cincinnati Reds Player Prop Facts

St. Louis Cardinals Player Prop Facts

Matchup/League Facts

Cardinals vs Reds Prediction


The Reds are 3-1 in their last 4 meetings against the Cardinals but are 1-2 in their last three visits in Cincinnati.

In this Cardinals vs Reds Prediction, the Reds are coming as -125 home favorites. The Cardinals have the pitching edge as Andre Pallante goes up against a struggling Chris Paddack. Paddack has been atrocious at home with a 15.88 home ERA and was torched in his previous start against the Cardinals this season with 5 earned runs. Pallante is coming off a quality start and the Cardinals are better against right-handed pitching and a very good road team, so I expect them to bounce back and win this one on the road.

Nikos Lagouretos's Pick: St. Louis Cardinals ML

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