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St. Louis Cardinals vs Baltimore Orioles Prediction 5/26/25 MLB Picks

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Baltimore Orioles (18-34) vs St. Louis Cardinals (30-23)

Game Info: Monday, May 26, 2025 at 3:05 pm (Oriole Park at Camden Yards)

The Line: Betting Odds: Baltimore Orioles -110 / St. Louis Cardinals -110 — Over/Under: 9.5

(Get latest betting odds)

The St. Louis Cardinals and Baltimore Orioles meet Monday in MLB action at Oriole Park at Camden Yards. Here’s a St. Louis Cardinals vs Baltimore Orioles Prediction. This article will include a St. Louis Cardinals vs Baltimore Orioles Pick.

St. Louis Cardinals Betting Preview

The St. Louis Cardinals are 30-23 on the year and play the Rangers, Royals, and Dodgers next. The St. Louis Cardinals are batting .261 on the season, have a .332 OBP, and a .389 slugging percentage. The St. Louis Cardinals’ pitching staff has a 3.73 ERA and a 1.22 WHIP. Brendan Donovan leads the St. Louis Cardinals with 65 hits and 22 RBI, while Lars Nootbaar and Willson Contreras have combined for 95 hits and 53 RBI. 

Erick Fedde gets the ball for the St. Louis Cardinals, and he is 3-3 with a 3.77 ERA and 34 strikeouts this season. Fedde is 2-0 with a 0.38 ERA and 12 strikeouts in his career against the Baltimore Orioles.

Baltimore Orioles Betting Preview

The Baltimore Orioles are 18-34 on the year and play the White Sox, Mariners, and Athletics next. The Baltimore Orioles are batting .234 on the season, have a .302 OBP, and a .386 slugging percentage. The Baltimore Orioles pitching staff has a 5.52 ERA and a 1.48 WHIP. Ryan O’Hearn leads the Baltimore Orioles with 49 hits and 18 RBI, while Gunnar Henderson and Jackson Holliday have combined for 92 hits and 36 RBI.

The Baltimore Orioles didn’t announce a starting pitcher at the time this article was published.

Why the Baltimore Orioles will win

Why the St. Louis Cardinals will win

Baltimore Orioles Player Prop Facts

St. Louis Cardinals Player Prop Facts

St. Louis Cardinals vs Baltimore Orioles Prediction

The Orioles didn’t announce a starting pitcher at the time this article was published, but it doesn’t matter. I’ve been fading the Orioles pretty much all season, and a couple of wins over the Red Sox don’t move the needle much. The Orioles are still 16 games below a .500 record, and only the Rockies have lost bettors more money this season. The Cardinals are coming off a nice sweep of the Diamondbacks, and Fedde is in a groove, allowing 20 hits and seven runs in his last 24.2 innings. In 29.2 road innings, Fedde has a 2.43 ERA and a .190 allowed batting average. Give me the Cardinals and the pick ’em price.

Randy Chambers's Pick: St. Louis Cardinals -110

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