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St. Louis Cardinals vs Atlanta Braves Prediction 4/22/25 MLB Picks

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Atlanta Braves (9-13) vs St. Louis Cardinals (9-14)

Game Info: Tuesday, April 22, 2025 at 7:15 pm (Truist Park)

The Line: Betting Odds: Atlanta Braves -135 / St. Louis Cardinals +114 — Over/Under: 8.5

(Get latest betting odds)

The St. Louis Cardinals and Atlanta Braves meet Tuesday in MLB action at Busch Stadium. Here’s a St. Louis Cardinals vs Atlanta Braves Prediction. This article will include a St. Louis Cardinals vs Atlanta Braves Pick.

St. Louis Cardinals Betting Preview

The St. Louis Cardinals are 9-14 on the year and play the Brewers, Reds, and Mets next. The St. Louis Cardinals are batting .264 on the season, have a .331 OBP, and a .405 slugging percentage. The St. Louis Cardinals’ pitching staff has a 4.38 ERA and a 1.21 WHIP. Brendan Donovan leads the St. Louis Cardinals with 32 hits and 13 RBI, while Nolan Arenado and Lars Nootbaar have combined for 42 hits and 21 RBI. 

Andre Pallante gets the ball for the St. Louis Cardinals, and he is 2-1 with a 3.22 ERA and 15 strikeouts this season. Pallante is 0-1 with a 12.15 ERA and 6 strikeouts in his career against the Atlanta Braves.

Atlanta Braves Betting Preview

The Atlanta Braves are 9-13 on the year and play the Diamondbacks, Rockies, and Dodgers next. The Atlanta Braves are batting .232 on the season, have a .309 OBP, and a .391 slugging percentage. The Atlanta Braves pitching staff has a 4.28 ERA and a 1.31 WHIP. Austin Riley leads the Atlanta Braves with 25 hits and 15 RBI, while Marcell Ozuna and Ozzie Albies have combined for 40 hits and 20 RBI.

The Atlanta Braves didn’t list a starting pitcher at the time this article was published.

Why the Atlanta Braves will win

Why the St. Louis Cardinals will win

Atlanta Braves Player Prop Facts

St. Louis Cardinals Player Prop Facts

St. Louis Cardinals vs Atlanta Braves Prediction

It would be nice to know who the Braves are throwing out there on the mound, but it probably doesn’t matter. As good as Pallante has been through 22.1 innings, it doesn’t mean much if the Cards can’t produce offense. The Cardinals have lost five straight games and have been held to four or fewer runs in six of their last seven games. The Braves are finally showing signs of getting their act together with four straight wins, and the offense has picked up. I’ll side with the Braves at home and the cheap price, regardless of who is on the mound.

Randy Chambers's Pick: Atlanta Braves -135

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