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Seattle Mariners vs St. Louis Cardinals Prediction 4/25/2026 Today’s MLB Picks

Apr 24, 2026; St. Louis, Missouri, USA; Seattle Mariners center fielder Julio Rodríguez (44) catches a fly ball against the St. Louis Cardinals during the seventh inning at Busch Stadium. Mandatory Credit: Jeff Curry-Imagn Images

Apr 24, 2026; St. Louis, Missouri, USA; Seattle Mariners center fielder Julio Rodríguez (44) catches a fly ball against the St. Louis Cardinals during the seventh inning at Busch Stadium. Mandatory Credit: Jeff Curry-Imagn Images

MATCHUP Seattle Mariners St. Louis Cardinals
Team Records 12-15 14-11
Where Busch Stadium, St. Louis, Missouri
When Saturday, April 25, 2026
Time 02:15 PM EDT
TV MLB.TV
The Seattle Mariners and St. Louis Cardinals meet Saturday in MLB action at Busch Stadium. Here’s a Seattle Mariners vs. St. Louis Cardinals Prediction. This article will include a Seattle Mariners vs. St. Louis Cardinals Pick.

Seattle Mariners Betting Preview


The Seattle Mariners are 12-15 on the year and play the Royals and Twins next. The Seattle Mariners are batting. 223 on the season, have a .319 OBP, and have a .360 slugging percentage. The Seattle Mariners pitching staff has a 3.37 ERA and a 1.21 WHIP. Randy Arozarena leads the Seattle Mariners with 28 hits and 10 RBI while Cole Young and Julio Rodriguez have combined for 46 hits and 20 RBI.

Bryan Woo gets the ball for the Seattle Mariners, and he is 1-2 with a 2.25 ERA and 26 strikeouts this season. This will be Woo’s second career game against the St. Louis Cardinals.

St. Louis Cardinals Betting Preview


The St. Louis Cardinals are 14-11 on the year and play the Pirates and Dodgers next. The St. Louis Cardinals are batting .230 on the season and have a .319 OBP, and a .371 slugging percentage. The St. Louis Cardinals pitching staff has a 4.70 ERA and a 1.41 WHIP. Jordan Walker leads the St. Louis Cardinals with 26 hits and 16 RBI while Alec Burleson and Ivan Herrera have combined for 46 hits and 29 RBI.

Matthew Liberatore gets the ball for the St. Louis Cardinals, and he is 0-1 with a 3.67 ERA and 16 strikeouts this season. Liberatore is 0-1 with a 13.50 ERA and 1 strikeout in his career against the Seattle Mariners.

Why the St. Louis Cardinals will win

Why the Seattle Mariners will win

Total Runs Facts

St. Louis Cardinals Player Prop Facts

Seattle Mariners Player Prop Facts

Matchup/League Facts

Seattle Mariners vs St. Louis Cardinals Prediction


The Mariners are going to be favored with the way Woo has pitched. We’re talking about a pitcher who has a 2.25 ERA and 0.88 WHIP through 32 innings. Liberatore has been far more hittable and has 10 walks in 27 innings. Still, the value is with the Cardinals at home and the more favorable price. The Mariners are just 2-8 on the road this season and these quick turnarounds and early start times usually favor the home team. Give me the Cardinals.

Randy Chambers's Pick: St. Louis Cardinals

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