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Seattle Mariners vs Houston Astros Prediction 5/25/25 MLB Picks

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Houston Astros (27-25) vs Seattle Mariners (29-22)

Game Info: Sunday, May 25, 2025 at 2:10 pm (Daikin Park)

The Line: Betting Odds: Houston Astros +110 / Seattle Mariners -130 — Over/Under: 8

(Get latest betting odds)

The Seattle Mariners and the Houston Astros meet Sunday in MLB action from Daikin Park. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Seattle Mariners vs. Houston Astros prediction.

Starting Pitching Matchup

The Seattle Mariners will send out Luis Castillo for the start here, and Castillo is 4-3 with a 3.20 ERA and 44 strikeouts this season. In his last five starts against the Astros, Castillo is 1-2 with a 2.90 ERA and 26 strikeouts. Colton Gordon will start this one for Houston and is 0-0 with a 5.59 ERA and 10 strikeouts this season. This will be Gordon’s first career start against Seattle.

Seattle Mariners Recap

The Seattle Mariners come into this game looking to bounce back from a 2-1 loss at the hands of the Astros in Saturday’s matchup to fall to 29-22 on the year. After this series, the Mariners will head home for a series against the Washington Nationals.

Mariners Alternate Wins & Losses In 6 Straight Games

Jorge Polanco has 37 hits, including 10 home runs and 30 RBIs, while Cal Raleigh has 47 hits with 10 doubles, a team-high 17 home runs, and 35 RBIs. Randy Arozarena has 41 hits with 11 doubles, 6 home runs, 21 RBIs, and 9 stolen bases. Julio Rodriguez also has 46 hits with a pair of triples, 9 home runs, 29 RBIs, and 6 stolen bases. Dylan Moore has 8 homers and 8 stolen bases as well this season. Rowdy Tellez has also added 8 home runs and 23 RBIs, while J.P. Crawford has 45 hits with 5 doubles, 4 home runs, and 19 RBIs.

Why the Seattle Mariners will win

Seattle Mariners Player Prop Facts

Houston Astros Recap

The Houston Astros come into this game looking to add on to their win over the Mariners from Saturday’s clash to improve their record to 27-25 on the year. After this series, the Astros will square off in a division series against the Athletics.

Astros Looking For Consistency

Jose Altuve has 50 hits, including 6 home runs and 18 RBIs. Jeremy Pena also has 58 hits with 6 homers and 25 RBIs with 6 stolen bases, while Yordan Alvarez has 4 doubles and 18 RBIs with 21 strikeouts as well. Jake Meyers has 7 doubles as well, and Christian Walker has also accrued a team-high 57 strikeouts so far this season. Altuve also has 4 stolen bases while Jake Meyers has a team-high 8 stolen bases this season. Isaac Paredes also has a team-high 11 home runs with 31 RBIs of his own, and Cam Smith has contributed 3 homers and 13 RBIs.

Why the Houston Astros will win

Houston Astros Player Prop Facts

Total Runs Facts

Seattle Mariners vs. Houston Astros Prediction

I’m leaning towards the Mariners here. I just haven’t loved what I’ve seen from Gordon up to this point, and I think the Mariners can get one more win in Houston to close out the series. The Mariners have a significant edge in starting pitching and have been able to do some damage at the plate as well, and I think they do enough against Gordon to get the win and split in the series.

Chris Ruffolo's Pick: Seattle Mariners -130

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