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Seattle Mariners vs Houston Astros Prediction 5/13/2026 Today’s MLB Picks

May 12, 2026; Houston, Texas, USA; Houston Astros second baseman Jose Altuve (27) reacts after batting during the eighth inning against the Seattle Mariners at Daikin Park. Mandatory Credit: Troy Taormina-Imagn Images

May 12, 2026; Houston, Texas, USA; Houston Astros second baseman Jose Altuve (27) reacts after batting during the eighth inning against the Seattle Mariners at Daikin Park. Mandatory Credit: Troy Taormina-Imagn Images

MATCHUP Seattle Mariners Houston Astros
Team Records 21-22 16-27
Spread -1.5 123 +1.5 -149
Moneyline -126 +104
Total Over 9 (-118) Under 9 (-102)
Where Daikin Park, Houston, Texas
When Wednesday, May 13, 2026
Time 08:10 PM EDT
TV MLB.TV
The Seattle Mariners and Houston Astros meet Wednesday in MLB action at Daikin Park. Here’s a Seattle Mariners vs. Houston Astros Prediction. This article will include a Seattle Mariners vs. Houston Astros Pick.

Seattle Mariners Betting Preview


The Seattle Mariners are 21-22 on the year and play the White Sox and Padres next. The Seattle Mariners are batting. 231 on the season, have a .320 OBP, and have a .380 slugging percentage. The Seattle Mariners’ pitching staff has a 3.67 ERA and a 1.22 WHIP. Randy Arozarena leads the Seattle Mariners with 47 hits and 16 RBI while Josh Naylor and Julio Rodriguez have combined for 85 hits and 39 RBI.

Bryce Miller gets the ball for the Seattle Mariners, and he was 4-6 with a 5.68 ERA and 74 strikeouts last season. Miller is 4-1 with a 2.55 ERA and 25 strikeouts in his career against the Houston Astros.

Houston Astros Betting Preview


The Houston Astros are 16-27 on the year and play the Rangers and Twins next. The Houston Astros are batting. 255 on the season, have a .330 OBP, and have a .421 slugging percentage. The Houston Astros’ pitching staff has a 5.61 ERA and a 1.59 WHIP. Yordan Alvarez leads the Houston Astros with 49 hits and 29 RBI while Jose Altuve and Christian Walker have combined for 82 hits and 37 RBI.

Lance McCullers Jr. gets the ball for the Houston Astros, and he is 2-3 with a 7.41 ERA and 37 strikeouts this season. McCullers is 10-3 with a 3.46 ERA and 133 strikeouts in his career against the Seattle Mariners.

Why the Houston Astros will win

Why the Seattle Mariners will win

Total Runs Facts

Houston Astros Player Prop Facts

Seattle Mariners Player Prop Facts

Matchup/League Facts

Seattle Mariners vs Houston Astros Prediction


I’m not excited to get behind Miller, who will make his season debut after dealing with an oblique injury. However, the Astros’ pitching remains god awful and that includes McCullers, who has a 7.41 ERA and 1.50 WHIP through 34 innings. In 19.2 frames at home, McCullers has a 7.32 ERA and .257 allowed batting average. McCullers has allowed 3 or more earned runs in each of his last 6 starts. Miller can’t be worse than that. Give me the M’s on the road.

Randy Chambers's Pick: Seattle Mariners

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