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San Francisco Giants vs San Diego Padres Prediction 4/30/25 MLB Picks

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San Diego Padres (18-11) vs San Francisco Giants (19-11)

Game Info: Wednesday, April 30, 2025 at 4:10 pm (Petco Park)

The Line: Betting Odds: San Diego Padres -135 / San Francisco Giants +114 — Over/Under: 7

(Get latest betting odds)

The San Francisco Giants and the San Diego Padres meet Wednesday in MLB action from Petco Park. We will look at this from a betting perspective and determine the best bets for this game. Here’s a San Francisco Giants vs. San Diego Padres prediction.

Starting Pitching Matchup

The San Francisco Giants will send out Landen Roupp for the start here, and Roupp is 2-1 with a 4.56 ERA and 31 strikeouts this season. This will be Roupp’s second career start against the Padres. Michael King will get the start for the Padres here, and King is 3-1 with a 2.18 ERA and 40 strikeouts this season. In his career, King is 2-0 with a 1.59 ERA and 18 strikeouts against the Giants.

San Francisco Giants Recap

The San Francisco Giants come into this game looking to respond to a 7-4 loss at the hands of the Padres to fall to 19-11 on the year. After this series, the Giants will take on the Colorado Rockies at home.

Giants Looking To Rebound

Jung Hoo Lee leads the Giants with 35 hits, including a team-high 11 doubles, along with a pair of triples, 3 home runs, and 16 RBIs with 3 stolen bases, while Heliot Ramos has 28 hits with 7 doubles, 3 home runs, and 10 RBIs. Wilmer Flores also has a team-high 7 home runs and 28 RBIs, while Mike Yastrzemski has 4 home runs with 13 RBIs and 6 doubles, and Tyler Fitzgerald has a team-high 5 stolen bases as well on the year.

Why the San Francisco Giants will win

San Francisco Giants Player Prop Facts

San Diego Padres Recap

The San Diego Padres will be out to build on their series-opening win over the Giants to improve their record to 18-11 on the year. After this series, the Padres will head on the road again for a series against the Pittsburgh Pirates.

Padres Snap Four-Game Losing Skid

Manny Machado has 28 hits, including a team-high 10 doubles and 6 stolen bases, while Fernando Tatis Jr. has 36 hits with a team-high 8 home runs and 18 RBIs, along with 7 stolen bases of his own this season. Luis Arraez has added 25 hits with 3 doubles, while Jackson Merrill’s added 14 hits with 3 home runs and 10 RBIs as well. Xander Bogaerts also has 8 doubles and 4 stolen bases this season. Gavin Sheets also has 4 doubles, 3 home runs, and 12 RBIs as well this season.

Why the San Diego Padres will win

San Diego Padres Player Prop Facts

Total Runs Facts

San Francisco Giants vs. San Diego Padres Prediction

I’m on the under in this game. Roupp and King are solid options for their respective rotations, and I think this could end up being a bit of a pseudo Pitcher’s duel. The bullpens on both sides have also been some of the best in baseball over the last couple of weeks and while we saw runs come in bunches in Tuesday’s matchup, one win is not going to convince me all of a sudden that these offenses are back in business and are going to be operating at a high level going forward. I still think this is going to end up being a low-scoring affair, so give me the under in this one.

Chris Ruffolo's Pick: Under 7

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