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San Francisco Giants vs San Diego Padres Prediction 8/19/2025 Today’s MLB Picks

Aug 18, 2025; San Diego, California, USA; San Diego Padres pitch hitter Ryan O'Hearn (32) flips his bat after hitting a two-run home run during the seventh inning against the San Francisco Giants at Petco Park. Mandatory Credit: David Frerker-Imagn Images

Aug 18, 2025; San Diego, California, USA; San Diego Padres pitch hitter Ryan O'Hearn (32) flips his bat after hitting a two-run home run during the seventh inning against the San Francisco Giants at Petco Park. Mandatory Credit: David Frerker-Imagn Images

MATCHUP Giants San Francisco Padres San Diego
Team Records 61-65 70-56
Where Petco Park, San Diego, California
When Tuesday, August 19, 2025
Time 09:40 PM EDT
TV Padres.TV

In this article, we will formulate a Giants vs Padres Prediction for this MLB game on Tuesday, August 19th at the Petco Park in the second game of this series, with the Giants having the 1-0 lead. Let’s take a look at the prediction for this MLB matchup.

San Diego Padres Preview

The San Diego Padres have a 69-56 record this season and are sitting on the second place of the NL West. They have a 38-21 home record, and are 51-70 in over/under. The Padres are coming off a 3-4 home defeat by the Giants, and have four consecutive losses. Under is 5-1-1 in their last 7 games and are playing the Dodgers and the Mariners next.

The Padres have a .251 batting average this season, .321 OBP and .383 Slugging percentage. San Diego’s pitching staff has a 3.58 ERA and 1.21 WHIP. Luis Arraez leads the Padres with 141 hits and team-high .291 batting average. Manny Machado leads the team in RBI, with 72, adding a team-high 20 home runs.

Nick Pivetta (R) is the projected starting pitcher for the Padres, and he has a 12-4 record, 2.87 ERA and 0.95 WHIP.

San Francisco Giants Preview

The San Francisco Giants have a 61-64 record this season and are sitting on the third place of the NL West. They have a 31-31 road record and are 57-63 in over/under. They are coming off a 4-3 road victory over the Padres, and have back-to-back wins. Under is 7-3-1 in their last 11 games and are playing the Cubs and the Brewers next.

The Giants have a .233 batting average this season, .309 OBP and .376 Slugging percentage. San Francisco’s pitching staff has a 3.67 ERA and 1.28 WHIP. Heliot Ramos leads the Giants with 128 hits and is the team’s best hitter, with a .267 batting average. Wilmer Flores leads the team in RBI with 63, while Willy Adames adds a team-high 19 home runs.

Kai-Wei Teng (R) is the projected starting pitcher for the Giants, and he has a 1-2 record, 9.90 ERA and 1.90 WHIP.

Why the San Diego Padres will win

Why the San Francisco Giants will win

Total Runs Facts

Matchup/League Facts

Giants vs Padres Prediction

The Padres are 8-3 in their last 11 meetings against the Giants, and are 2-1 in their last three meetings in San Diego. Under is 6-2 in their last 8 meetings.

In this Giants vs Padres Prediction, the Padres are coming as -235 home favorites. The Padres have a better overall record and have been very strong at home, and have a huge pitching advantage in this game, as Pivetta takes the mound. He has been excellent this season, even better at home, and in great form lately, with a 2.81 ERA in his last five starts. Kai-Wei Teng has been torched in his two starts this season, having given up 11 runs in just 4.3 innings pitched, and one of his two starts was against the Padres, who torced him for 6 runs. San Diego has the best bullpen in the league, and are hitting better righties, so I expect them to win comfortably in this one and cover the runline.

Nikos Lagouretos's Pick: San Diego Padres -1.5

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