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San Francisco Giants vs Philadelphia Phillies Prediction 4/16/25 MLB Picks

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Philadelphia Phillies (10-7) vs San Francisco Giants (12-5)

Game Info: Wednesday, April 16, 2025 at 6:45 pm (Citizens Bank Park)

The Line: Betting Odds: Philadelphia Phillies -148 / San Francisco Giants +124 — Over/Under: 7.5

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The San Francisco Giants and the Philadelphia Phillies meet Wednesday in MLB action from Citizens Bank Park. We will look at this from a betting perspective and determine the best bets for this game. Here’s a San Francisco Giants vs. Philadelphia Phillies prediction.

Starting Pitching Matchup

The San Francisco Giants will send out Robbie Ray for the start here, and Ray is 3-0 with a 2.93 ERA and 13 strikeouts this season. In his last five starts against the Phillies, Ray is 3-1 with a 5.40 ERA and 41 strikeouts. Aaron Nola will get the start here and is 0-3 with a 5.51 ERA and 17 strikeouts this season. In his last five starts against the Giants, Nola is 2-1 with a 6.66 ERA and 18 strikeouts.

San Francisco Giants Recap

The San Francisco Giants come into this game looking to rebound from a 6-4 loss at the hands of the Phillies on Tuesday to fall to 12-5 on the year. After this series, the Giants will head on the road again for a series against the Angels.

Giants Looking For Back-To-Back Series Wins

Jung Hoo Lee leads the Giants with 21 hits, including a team-high 9 doubles, along with 3 home runs and 12 RBIs, with 3 stolen bases, while Heliot Ramos has 16 hits with 5 doubles, 3 home runs and 9 RBIs. Wilmer Flores also has a team-high 6 home runs and 21 RBIs, while Mike Yastrzemski has 3 home runs with 9 RBIs and 4 doubles, and Tyler Fitzgerald has a team-high 4 stolen bases as well on the year.

Why the San Francisco Giants will win

San Francisco Giants Player Prop Facts

Philadelphia Phillies Recap

The Philadelphia Phillies will try to win the rubber match of the series after improving to 10-7 on the year. After this series, the Phillies will welcome the Miami Marlins to town for a division series.

Phillies Trying To Snap Series Losing Skid

Nick Castellanos has a team-high 19 hits with 5 doubles, including 3 home runs and 11 RBIs, while Kyle Schwarber has 16 hits with a team-high 6 home runs and 12 RBIs as well on the year. Bryce Harper and Trea Turner each have a team-high 4 stolen bases, with Turner logging 3 doubles while Harper has 3 home runs and 7 RBIs. Max Kepler has 4 doubles and Bryson Stott has 3 doubles, while J.T. Realmuto also has 4 stolen bases this season.

Why the Philadelphia Phillies will win

Philadelphia Phillies Player Prop Facts

Total Runs Facts

San Francisco Giants vs. Philadelphia Phillies Prediction

I’m on the Giants here. I know Nola probably isn’t as bad as his numbers would indicate, but he’s had a problem with giving up home runs, and the Giants continue to be undervalued this season. Robbie Ray’s been rock solid, and the Phillies have been less effective against lefties as well this season, and even if Nola had a good start, the Giants have a serious edge in the bullpen. Give me the Giants in this one with the plus money attached.

Chris Ruffolo's Pick: San Francisco Giants +124

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