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San Francisco Giants vs Houston Astros Prediction 4/2/25 MLB Picks

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Houston Astros (2-3) vs San Francisco Giants (4-1)

Game Info: Wednesday, April 2, 2025 at 4:10 pm (Daikin Park)

The Line: Betting Odds: Houston Astros -162 / San Francisco Giants +136 — Over/Under: 8

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In this article, we will formulate a Giants vs Astros prediction for this MLB game on Wednesday, April 2, at Daikin Park in Houston, Texas. Let’s take a look at the prediction for this MLB matchup.

San Francisco Giants Betting Preview

The San Francisco Giants (4-1, 4-1 Away) secured a series win over the Cincinnati Reds on the road as they won two of three games to open a new season. The Giants then beat the Astros 7-2 and 3-1 in the first two games of the current series and now look to sweep Houston. Willy Adames led the Giants in a 3-1 victory with a couple of RBIs, while Logan Webb got a win after allowing a run on five hits with six strikeouts and no walks in 7.0 innings.

This season, the Giants average 5.25 runs per game (11th in the MLB) on a .226/.276/.406 slash line. Regarding pitching, the Giants’ staff has a 3.09 ERA (8th) and 0.97 WHIP (6th). Wilmer Flores leads the Giants with a .222 batting average, three home runs, and eight RBI this season.

The projected starting pitcher for the Giants is Lander Roupp, who had a 1-2 record in four starts last season with a 3.58 ERA and 1.37 WHIP over 50.1 innings of work. Lopez took a loss against the Cards this year and posted a 3.60 ERA in 5.0 innings.

Houston Astros Betting Preview

The Houston Astros (2-3, 2-3 Home) beat the New York Mets 2-1 in a three-game series to start the season. All three games were low-scoring, as the teams failed to combine for more than four runs. The Astros then lost a pair of games to the Giants, allowing ten and scoring just three runs in the process. In a most recent 3-1 defeat, Jose Altuve scored a solo homer, while Hayden Wesneski took a loss after allowing three runs on two hits, with six strikeouts and three walks in 5.0 innings.

This year, the Astros average 2.00 runs per game (28th in the MLB) on a .157/.269/.200 triple-slash. When it comes to pitching, the Astros’ staff has a 2.75 ERA (7th) and 1.08 WHIP (7th). Jose Altuve leads the Astros with a .389 batting average, one home run, and one RBI this season.

Framber Valdez will take the mound for the Astros on Wednesday. The 31-year-old southpaw had a 15-7 record last season in 28 starts with a 2.91 ERA and 1.11 WHIP in 176.1 innings. This season, Valdez started with a win in a shutout of the Mets when he allowed four hits with four strikeouts and two walks over 7.0 innings of work.

Why the Astros will beat the Giants

Total Runs Facts

Giants vs Astros Prediction

The Giants won eight of the previous ten H2H encounters, including six of the last seven. Landen Roupp is an inexperienced pitcher, and I think he will struggle against the Astros, who still haven’t found their offensive rhythm this season. Framber Valdez, on the other hand, had a poor outing against the Giants last year, but he will get a quality start in this one after a strong display against the Mets, who, honestly, have better batters in their lineup than the Giants. Expect the hosts to bounce back and avoid a series sweep.

Oliver Zivic's Pick: Astros ML

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