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San Francisco Giants vs Cincinnati Reds Prediction 3/29/25 MLB Picks

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Albert Cesare/The Enquirer / USA TODAY NETWORK

Cincinnati Reds (0-1) vs San Francisco Giants (1-0)

Game Info: Saturday, March 29, 2025 at 4:10 pm (Great American Ball Park)

The Line: Betting Odds: Cincinnati Reds -125 / San Francisco Giants +105 — Over/Under: 8.5

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In this article, we will formulate a San Francisco Giants vs Cincinnati Reds prediction for this MLB game on Saturday, March 29th, at Great American Ball Park in Cincinnati, Ohio. Let’s take a look at the prediction for this MLB matchup. 

San Francisco Giants Betting Preview

The San Francisco Giants are 1-0 this year after they defeated Cincinnati by a score of 6-4 on Thursday. San Francisco trailed 3-0 after the third inning, but they were able to score the next six runs and secure the win. The Giants scored two runs in the fourth and four in the ninth, and they totaled six hits in the process. Ramos went 1-4 with one home run and two RBIs in the game, while Flores went 1-4 with one home run and three RBIs. Logan Webb started for the Giants, but he allowed six hits and three earned runs over 5.0 innings of work. Rodriguez, Miller, and Rogers all pitched scoreless innings in relief, while Walker allowed one earned run in the ninth but did get the save. 

Last season, the San Francisco pitching staff had a 4.10 ERA with a 1.30 WHIP and a .246 opponent batting average, while the offense scored 693 runs with a .239 batting average and a .305 on-base percentage. The Giants were right in the middle of the pack in team ERA and runs scored last season, but they need to really improve if they want to compete in the NL West. The Giants were led by Matt Chapman, who hit .247 with 27 home runs and 78 RBIs last year. The projected starting pitcher for San Francisco is Justin Verlander, who was 5-6 with a 5.48 ERA and a 1.38 WHIP over 90.1 innings pitched for the Astros last year. 

Cincinnati Reds Betting Preview

The Cincinnati Reds are 0-1 this season after they lost to San Francisco by a score of 6-4 in their first game. Cincinnati took an early 3-0 lead on two different RBI singles from Candelario, but they allowed the next six runs in the game for the loss. The Reds did get one run back in the ninth but fell short in the comeback attempt. Candelario went 2-3 with three RBIs in the game, while Friedl went 2-5 with one RBI. Hunter Greene was the starting pitcher for Cincinnati, and he allowed three hits and two earned runs over 5.0 innings. Barlow, Pagan, and Santillan threw scoreless innings out of the bullpen, but Gibaut allowed four earned runs in 0.2 innings for the loss. The Reds will meet the Rangers after this series.

Last year, the Cincinnati pitching staff had a 4.09 ERA with a 1.25 WHIP and a .239 opponent batting average, while their offense scored 699 runs with a .231 batting average and a .305 on-base percentage. Cincinnati was also in the middle of the MLB in team ERA and runs scored, and they also need big improvement to compete with the Brewers. The Reds were led by Elly De La Cruz, who hit .259 with 25 home runs and 76 RBIs last year. The projected starting pitcher for Cincinnati is Nick Lodolo, who was 9-6 with a 4.76 ERA and a 1.20 WHIP over 115.1 innings pitched in 2024.

Why the Reds will beat the Giants 

Total Runs Facts

Cincinnati Reds Player Prop Facts

San Francisco Giants Player Prop Facts

San Francisco Giants vs Cincinnati Reds Prediction 

The Giants were able to have a huge ninth inning to steal the win in game one of this series on Thursday, but they will be going against Lodolo, who is going to have a solid season, in my opinion. Neither offense is very high-scoring, but I can’t trust Verlander on the mound. JV has had a fantastic career, but he is 42 years old now and had a rough season in Houston last year. Give me the Reds to get the win here. 

David Racey's Pick: Reds ML

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