| MATCHUP | San Francisco Giants | Cincinnati Reds |
|---|---|---|
| Team Records | 6-12 | 11-7 |
| Where | Great American Ball Park, Cincinnati, Ohio | |
| When | Wednesday, April 15, 2026 | |
| Time | 06:40 PM EDT | |
| TV | MLB.TV | |
The San Francisco Giants and Cincinnati Reds meet Wednesday in MLB action at Great American Ball Park. Here’s a San Francisco Giants vs. Cincinnati Reds Prediction. This article will include a San Francisco Giants vs. Cincinnati Reds Pick.
San Francisco Giants Betting Preview
The San Francisco Giants are 6-11 on the year and play the Dodgers and Nationals next. The San Francisco Giants are batting. 201 on the season, have a .297 OBP, and have a .327 slugging percentage. The San Francisco Giants pitching staff has a 3.86 ERA and a 1.37 WHIP. Luis Arraez leads the San Francisco Giants with 20 hits and 6 RBI while Willy Adames and Matt Chapman have combined for 36 hits and 13 RBI.
Tyler Mahle gets the ball for the San Francisco Giants, and he is 0-2 with a 4.30 ERA and 15 strikeouts this season. This will be Mahle’s first career game against the Cincinnati Reds.
Cincinnati Reds Betting Preview
The Cincinnati Reds are 10-7 on the year and play the Rays and Twins next. The Cincinnati Reds are batting. 201 on the season, have a .297 OBP, and have a .327 slugging percentage. The Cincinnati Reds pitching staff has a 3.86 ERA and a 1.37 WHIP. Elly De La Cruz leads the Cincinnati Reds with 19 hits and 10 RBI, while Sal Stewart and Eugenio Suarez have combined for 31 hits and 19 RBI.
Rhett Lowder gets the ball for the Cincinnati Reds, and he is 1-1 with a 3.31 ERA and 11 strikeouts this season. This will be Lowder’s first career game against the San Francisco Giants.
Why the Cincinnati Reds will win
- The Giants have lost each of their last three games as favorites.
- The underdogs have won six of the Giants’ last nine games.
- The Giants have failed to cover the run line in each of their last four games as favorites against NL Central opponents.
- The Reds have covered the run line in six of their last seven games as home underdogs against NL West opponents.
- The Reds have led after 3 innings in each of their last three games against the Giants.
- The Reds have led after 5 innings in each of their last three games against the Giants.
Why the San Francisco Giants will win
- The Giants have won each of their last six games as road favorites against the Reds.
- The Reds have lost five of their last six games against the Giants following a win.
- The Giants have covered the run line in each of their last eight games against NL Central opponents following a road loss.
- The Reds have failed to cover the run line in eight of their last nine home games against teams that held a losing record.
- The Giants have led after 5 innings in four of their last five games as road favorites against NL Central opponents.
- The Reds have trailed after 3 innings in four of their last five home games against opponents that held a losing record.
Total Runs Facts
- Seven of the Reds’ last eight games as underdogs against National League opponents have gone OVER the total runs line.
- Four of the Giants’ last five games as road favorites have gone OVER the total runs line.
- The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the last six games between the Giants and Reds.
- The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the Giants’ last four night games at Great American Ball Park.
Cincinnati Reds Player Prop Facts
- Elly De La Cruz has recorded at least one hit in each of the Reds’ last eight home games against NL West opponents.
- JJ Bleday has hit a home run in three of his last five home appearances against NL West opponents that held a losing record.
- Elly De La Cruz ranks T8th in the league in Home Runs (5) this season.
San Francisco Giants Player Prop Facts
- Heliot Ramos has hit a home run in each of the Giants’ last two games as road favorites against the Reds.
- Rafael Devers has recorded at least one hit in each of his nine previous appearances against the Reds after playing the previous day.
- Tyler Mahle has recorded a win in three of his last four road appearances against NL opponents.
Matchup/League Facts
- The Reds rank T29th in the league for RBIs this season (48).
- The Reds rank 29th in the league for batting average this season (.201).
- The Giants rank 30th in the league for steals this season (5).
- The Giants rank 30th in the league for walks this season (34).
San Francisco Giants vs Cincinnati Reds Prediction
The Giants still aren’t hitting the baseball and they’re getting tougher and tougher to back. However, let’s not act like the Reds are world beaters and this will be a homecoming for Mahle, as he was drafted by the Reds and spent his first several seasons with the franchise. I’m sure this start means a little more to Mahle and he’ll want to leave with a victory. The jury is still out on Lowder, who has just 9 career starts. Pick a price, and I’ll give the edge to the Giants, but there are probably better options out there.