San Diego Padres vs San Francisco Giants Prediction 6/5/25 MLB Picks

The San Diego Padres are visiting the San Francisco Giants on Thursday, June 5th at the Oracle Park in the fourth and final game of this series, with the Padres having the 2-1 lead. We will look at this from a betting perspective and determine the best bets for this game. Here’s the San Diego Padres vs San Francisco Giants Prediction. We will examine:

The San Francisco Giants’ recent form and player performance

The San Diego Padres’ recent form and player performance

Recent betting trends and streaks involving the San Francisco Giants

Recent betting trends and streaks involving the San Diego Padres

Recent betting trends in games played between the San Diego Padres vs San Francisco Giants

A summary that ties it all together and produces a favorable betting outcome for the San Diego Padres vs San Francisco Giants game

San Francisco Giants Preview

The San Francisco Giants have a 34-28 record this season and are sitting in third place in the NL West. They have an 18-11 home record and are 29-33 in over/under. They are coming off a 6-5 home victory over the Padres, which ended their previous two-game losing streak. Under is 11-1 in their last 12 games, and are playing the Rockies and the Braves next.

The Giants have a .231 batting average this season, a .309 OBP, and a .372 Slugging percentage. San Francisco’s pitching staff has a 3.06 ERA and 1.20 WHIP.  Heliot Ramos leads the Giants with 68 hits and is the team’s best hitter, with a .292 batting average. Wilmer Flores leads the team in RBI with 47, while Matt Chapman leads the team in home runs with 11.

Robbie Ray (L) will take the mound for the Giants, and he has a 7-1 record, 2.43 ERA, and 1.11 WHIP. He has been even better at home, with a 1.89 ERA across six home starts, and he has been in excellent form, having one earned run or less in five of his last six starts. Robbie Ray has a record of 5-6 with an ERA of 4.27 and 134 strikeouts in 18 appearances against the Padres in his career.

San Diego Padres Preview

The San Diego Padres have a 35-25 record this season and are sitting in second place in the NL West. They have a 15-15 road record, and are 25-33 in over/under. The Padres are coming off a 5-6 road defeat by the Giants, which ended their previous three-game winning streak. Under is 4-2 in their last 6 games, and they are playing the Dodgers and the Brewers next. 

The Padres have a .249 batting average this season, a .315 OBP, and a .381 Slugging percentage. San Diego’s pitching staff has a 3.56 ERA and 1.20 WHIP.  Manny Machado leads the Padres with 70 hits and a team-high .314 batting average. Gavin Sheets leads the team in RBI, with 38, while Fernando Tatis Jr. adds a team-high 13 home runs. 

Dylan Cease (R) will take the mound for the Padres, and he has a 1-4 record, 4.66 ERA, and 1.29 WHIP. He has weaker on the road, with a 5.68 ERA across six road starts, and he has been in poor form lately, having given up 3 earned runs in each of his last three starts. Dylan Cease has a 3-2 record with an ERA of 2.76 and 39 strikeouts in 6 appearances against the Giants in his career.

Why the San Francisco Giants will win

• The Giants have won each of their last eight games as home favorites against NL West opponents following a home win.
• The Padres have lost six of their last eight games against teams that held a winning record.
• The Giants have covered the run line in seven of their last eight games as home favorites against NL West opponents following a home win.
• The Giants have led after 3 innings in four of their last five games as home favorites against National League opponents.
• The Padres have trailed after 5 innings in each of their last four road day games.

Why the San Diego Padres will win

• The Padres have won each of their last seven games as underdogs against NL West opponents following a road loss.
• The Giants have lost each of their last five games as favorites following a win.
• The Padres have covered the run line in each of their last 12 games as underdogs against the Giants.
• The Giants have failed to cover the run line in each of their last eight games following a win.
• The Padres have led after 3 innings in five of their last six day games against NL West opponents that held a winning record.
• The Giants have trailed after 5 innings in each of their last four day games against opponents that held a winning record.

Total Runs Facts

• Each of the Giants’ last eight games as favorites have gone UNDER the total runs line.
• Six of the Padres’ last seven games as underdogs against the Giants have gone UNDER the total runs line.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in seven of the Giants’ last eight day games at Oracle Park.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in eight of the Padres’ last 10 games as underdogs.

Matchup/League Facts

• The Giants rank 1st in the league for home runs allowed this season (41).
• The Giants rank 2nd in the league for ERA this season (3.06).
• The Padres rank 1st in the league for strikeouts against this season (415).
• The Padres rank 4th in the league for hits allowed this season (449).

San Diego Padres vs San Francisco Giants Prediction

The Padres are 7-1 in their last 8 meetings against the Giants, and are 4-1 in their last 5 visits to San Francisco. Under is 5-2 in their last 7 meetings in San Francisco.

In this San Diego Padres vs San Francisco Giants Prediction, the Giants are coming as -120 home favorites. Both teams have almost identical overall records, but San Francisco has been dominant at home, while San Diego has been average on the road. The Giants have the best bullpen in the league, and they are better against righties, while the Padres struggle against lefties, with just 3.8 runs per game against left-handed pitching.

Giants also have the pitching advantage, as Ray has been excellent this season, better at home, and looking sharp lately, while Cease has been shaky this season and bad on the road. Take the San Francisco Giants to get the job done at home.

Nikos Lagouretos's Pick: San Francisco Giants ML