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San Diego Padres vs Detroit Tigers Prediction 4/23/25 MLB Picks

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Detroit Tigers (14-10) vs San Diego Padres (17-7)

Game Info: Wednesday, April 23, 2025 at 1:10 pm (Comerica Park)

The Line: Betting Odds: Detroit Tigers -162 / San Diego Padres +136 — Over/Under: 8.5

(Get latest betting odds)

The San Diego Padres and Detroit Tigers meet Wednesday in MLB action at Comerica Park. Here’s a San Diego Padres vs Detroit Tigers Prediction. This article will include a San Diego Padres vs Detroit Tigers Pick.

San Diego Padres Betting Preview

The San Diego Padres are 17-7 on the year and play the Rays, Giants, and Pirates next. The San Diego Padres are batting .270 on the season, have a .341 OBP, and a .413 slugging percentage. The San Diego Padres pitching staff has a 2.77 ERA and a 1.11 WHIP. Fernando Tatis Jr. leads the San Diego Padres with 31 hits and 17 RBI, while Manny Machado and Luis Arraez have combined for 51 hits and 17 RBI. 

Kyle Hart gets the ball for the San Diego Padres, and he is 2-1 with a 6.48 ERA and 10 strikeouts this season. This will be Hart’s first career game against the Detroit Tigers.

Detroit Tigers Betting Preview

The Detroit Tigers are 14-10 on the year and play the Orioles, Astros, and Angels next. The Detroit Tigers are batting .244 on the season, have a .323 OBP, and a .379 slugging percentage. The Detroit Tigers’ pitching staff has a 3.07 ERA and a 1.14 WHIP. Spencer Torkelson leads the Detroit Tigers with 24 hits and 21 RBI, while Kerry Carpenter and Zach McKinstry have combined for 45 hits and 23 RBI.

Reese Olson gets the ball for the Detroit Tigers, and he is 2-1 with a 4.50 ERA and 18 strikeouts this season. This will be Olson’s second career game against the San Diego Padres.

Why the Detroit Tigers will win

Why the San Diego Padres will win

Detroit Tigers Player Prop Facts

San Diego Padres Player Prop Facts

San Diego Padres vs Detroit Tigers Prediction

The Tigers continue to have offensive issues lately as they’ve scored three or fewer runs in five of their last eight games. Olson also hasn’t been great this season, allowing 21 hits and 10 runs in 20 innings. Hart has had his issues as well, allowing 18 hits and 12 runs in 16.2 innings, but the Padres have been so good overall that they’ve managed to win three of his four starts. I’m just not trying to step in front of the Padres, especially when getting the more favorable price. This line is strange, but I’m not asking any questions. Give me the Padres.

Randy Chambers's Pick: San Diego Padres +136

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