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San Diego Padres vs Detroit Tigers Prediction 4/21/25 MLB Picks

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Detroit Tigers (13-9) vs San Diego Padres (16-6)

Game Info: Monday, April 21, 2025 at 6:40 pm (Comerica Park)

The Line: Betting Odds: Detroit Tigers -130 / San Diego Padres +110 — Over/Under: 8

(Get latest betting odds)

The San Diego Padres and Detroit Tigers meet Monday in MLB action at Comerica Park. Here’s a San Diego Padres vs Detroit Tigers Prediction. This article will include a San Diego Padres vs Detroit Tigers Pick.

San Diego Padres Betting Preview

The San Diego Padres are 16-6 on the year and play the Rays, Giants, and Pirates next. The San Diego Padres are batting .276 on the season, have a .346 OBP, and a .424 slugging percentage. The San Diego Padres pitching staff has a 2.74 ERA and a 1.09 WHIP. Fernando Tatis Jr. leads the San Diego Padres with 29 hits and 16 RBI, while Luis Arraez and Manny Machado have combined for 50 hits and 17 RBI. 

Randy Vasquez gets the ball for the San Diego Padres, and he is 1-1 with a 1.74 ERA and 8 strikeouts this season. This will be Vasquez’s second career game against the Detroit Tigers.

Detroit Tigers Betting Preview

The Detroit Tigers are 13-9 on the year and play the Orioles, Astros, and Angels next. The Detroit Tigers are batting .246 on the season, have a .321 OBP, and a .387 slugging percentage. The Detroit Tigers’ pitching staff has a 3.12 ERA and a 1.14 WHIP. Kerry Carpenter leads the Detroit Tigers with 23 hits and 11 RBI, while Spencer Torkelson and Riley Greene have combined for 42 hits and 29 RBI.

Keider Montero gets the ball for the Detroit Tigers, and he is 0-1 with a 9.00 ERA and 8 strikeouts this season. This will be Montero’s second career game against the San Diego Padres.

Why the Detroit Tigers will win

Why the San Diego Padres will win

Detroit Tigers Player Prop Facts

San Diego Padres Player Prop Facts

San Diego Padres vs Detroit Tigers Prediction

The Padres continue to be one of the more consistent teams in baseball, and they’re throwing out Vazquez, who has been fantastic so far. In 20.2 innings, Vazquez has allowed 14 hits and four earned runs, and that’s with walking 14. Vazquez has dealt with a lot of traffic this season, but it hasn’t mattered much. Montero hasn’t been great through 17 career starts, as he has a 4.96 ERA and 1.35 WHIP, and he was rocked in his first start this season. It’s wild that we’re getting the Padres as a dog in this spot, but I’m not asking any questions. Give me the Padres. 

Randy Chambers's Pick: San Diego Padres +110

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