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San Diego Padres vs Chicago Cubs Prediction 9/30/2025 Today’s MLB Picks

Sep 27, 2025; San Diego, California, USA; San Diego Padres right fielder Fernando Tatis Jr. (23) is congratulated by Luis Arraez (4) after hitting a solo home run during the first inning against the Arizona Diamondbacks at Petco Park. Mandatory Credit: Denis Poroy-Imagn Images

Sep 27, 2025; San Diego, California, USA; San Diego Padres right fielder Fernando Tatis Jr. (23) is congratulated by Luis Arraez (4) after hitting a solo home run during the first inning against the Arizona Diamondbacks at Petco Park. Mandatory Credit: Denis Poroy-Imagn Images

MATCHUP Padres San Diego Cubs Chicago
Team Records 90-72 92-70
When Tuesday, September 30, 2025
Time 03:00 PM EDT
TV ABC

The San Diego Padres and the Chicago Cubs meet Tuesday in MLB action from Wrigley Field. We will look at this from a betting perspective and determine the best bets for this game. Here’s a San Diego Padres vs. Chicago Cubs prediction.

Starting Pitching Matchup

The San Diego Padres will send out Nick Pivetta for the start here and Pivetta was 13-5 with a 2.87 ERA and 190 strikeouts in the regular season. Matthew Boyd will get the start for the Cubs and was 14-8 with a 3.21 ERA and 154 strikeouts in the regular season.

San Diego Padres Recap

The San Diego Padres come into this game after finishing 90-72 on the year and finishing in a Wild Card spot.

Padres Make 4th Playoff Appearance Last 6 Seasons

Manny Machado has 169 hits including a team-high 33 doubles, 27 home runs, 95 RBIs and 14 stolen bases while Fernando Tatis Jr. has 159 hits with 25 home runs and 71 RBIs along with 32 stolen bases of his own this season. Luis Arraez has added 181 hits with 30 doubles, 4 triples, 8 home runs and 61 RBIs while Jackson Merrill’s added 116 hits with 16 home runs and 67 RBIs as well. Xander Bogaerts also has 30 doubles and 20 stolen bases as well this season. Gavin Sheets also has 28 doubles, 19 home runs and 71 RBIs as well this season.

Chicago Cubs Recap

The Chicago Cubs come into the postseason after finishing with an overall record of 92-70 this season. 

Cubs In First Non-Covid Postseason Since 2018

Ian Happ has 138 hits with 32 doubles, 23 home runs and 79 RBIs. Kyle Tucker has 133 hits including 25 doubles, 4 triples, 22 home runs and 73 RBIs while Seiya Suzuki also has 140 hits with 31 doubles and 32 home runs and 103 RBIs of his own. Pete Crow-Armstrong also has contributed 146 hits, 37 doubles, 4 triples, 31 home runs and 95 RBIs as well this season. Dansby Swanson has added 24 home runs and 77 RBIs, while also having 168 strikeouts and Suzuki has 164 strikeouts so far this season. Crow-Armstrong also has a team-high 35 stolen bases while Nico Hoerner has 29 stolen bases this season. Tucker’s also added 25 stolen bases while Michael Busch has also chipped in 25 doubles, 5 triples, 34 home runs and 90 RBIs this season.

San Diego Padres @ the Chicago Cubs Betting Trends: September 30, 2025

Why the Chicago Cubs will win

Why the San Diego Padres will win

Total Runs Facts

Chicago Cubs Player Prop Facts

San Diego Padres Player Prop Facts

Matchup/League Facts

San Diego Padres vs. Chicago Cubs Prediction

I’m on the Padres here. I just think the Padres are in prime position for an upset here, as the Cubs’ starters have been faltering down the stretch and that includes Matthew Boyd, who really just was not doing well to close out the year. He’s been great at Wrigley Field this season, but I just don’t see any way to get on board with him and even if he has a decent outing, the Padres have a significant edge in my eyes in the bullpen as well. I think the Padres have a great amount of value here. Give me San Diego.

Chris Ruffolo's Pick: San Diego +101

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