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Pittsburgh Pirates vs Milwaukee Brewers Prediction 4/25/2026 Today’s MLB Picks

Sep 26, 2025; Cumberland, Georgia, USA; Pittsburgh Pirates pitcher Mitch Keller (23) pitches the ball against the Atlanta Braves during the first inning at Truist Park. Mandatory Credit: Jordan Godfree-Imagn Images

Sep 26, 2025; Cumberland, Georgia, USA; Pittsburgh Pirates pitcher Mitch Keller (23) pitches the ball against the Atlanta Braves during the first inning at Truist Park. Mandatory Credit: Jordan Godfree-Imagn Images

MATCHUP Pittsburgh Pirates Milwaukee Brewers
Team Records 15-11 13-12
Spread +1.5 -186 -1.5 153
Moneyline +119 -143
Total Over 8 (-112) Under 8 (-108)
Where American Family Field, Milwaukee, Wisconsin
When Saturday, April 25, 2026
Time 07:10 PM EDT
TV MLB.TV
In this article, we will formulate a Pirates vs Brewers Prediction for this MLB matchup on Saturday, April 25th in the second game of this series. Let’s take a look at the prediction for this MLB matchup.

Milwaukee Brewers Preview


The Milwaukee Brewers have a 13-12 record this season and are sitting in the fifth place of the NL Central. They have a 7-6 home record and are coming off a 0-6 home loss against the Pirates. Their previous three games were a 4-5 loss, a 2-5 loss and a 12-4 win on the road against the Tigers.

The Brewers have a .233 batting average this season, .333 OBP and .354 Slugging percentage. Milwaukee’s pitching staff has a 3.98 ERA and 1.33 WHIP. William Contreras is the team’s best hitter with a .278 batting average. Brice Turang leads the team in RBI with 18, and Gary Sanchez adds a team‑high 5 home runs.

Jacob Misiorowski (R) is the projected starting pitcher for the Brewers, and he has a 1-2 record, 3.04 ERA and 1.09 WHIP.

Pittsburgh Pirates Preview


The Pittsburgh Pirates have a 15-11 record this season and are sitting in the third place of the NL Central. They have a 7-6 away record and are coming off a 6-0 road win against the Brewers. Their previous three games were a 1-6 loss, an 8-4 win and a 1-5 loss on the road against the Rangers.

The Pirates have a .246 batting average this season, .330 OBP and .386 Slugging percentage. Pittsburgh’s pitching staff has a 3.32 ERA and 1.25 WHIP. Ryan O’Hearn is the team’s best hitter with a .333 batting average. Oneil Cruz leads the team in RBI with 24, adding a team‑high 8 home runs.

Mitch Keller (R) is the projected starting pitcher for the Pirates, and he has a 2-1 record, 2.79 ERA and 1.10 WHIP.

Pittsburgh Pirates @ Milwaukee Brewers Betting Trends: April 25, 2026


Why the Milwaukee Brewers will win


Why the Pittsburgh Pirates will win

Total Runs Facts

Milwaukee Brewers Player Prop Facts

Pittsburgh Pirates Player Prop Facts

Matchup/League Facts

Pirates vs Brewers Prediction


The Brewers are 8-1 in their last 9 meetings against the Pirates and are 6-1 in their last 7 meetings in Milwaukee.

In this Pirates vs Brewers Prediction, the Brewers are coming as -135 home favorites. The Pirates won yesterday with Skenes on the mound and the Brewers have now lost three straight. Both pitchers have been very good this season with a combined 5.83 ERA and Keller’s only road start was a shutout and Misiorowski has been better at home. Yesterday’s game had 6 total runs and I don’t expect the script to flip today. Take the under 8.

Nikos Lagouretos's Pick: Under 8

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