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Pittsburgh Pirates vs Arizona Diamondbacks Prediction 5/27/25 MLB Picks

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Arizona Diamondbacks (27-27) vs Pittsburgh Pirates (19-36)

Game Info: Tuesday, May 27, 2025 at 9:40 pm (Chase Field)

The Line: Betting Odds: Arizona Diamondbacks -258 / Pittsburgh Pirates +210 — Over/Under: 9

(Get latest betting odds)

In this article, we will formulate a Pirates vs Diamondbacks prediction for this MLB game on Tuesday, May 27, at Chase Field in Phoenix, Arizona. Let’s take a look at the prediction for this MLB matchup.

Pittsburgh Pirates Betting Preview

The Pittsburgh Pirates (19-36, 6-20 Away) were in fine form with four wins in five games, but now lost back-to-back games to the Milwaukee Brewers and in the opening game of this series to the Arizona Diamondbacks. For the second time in ten days, the Pirates failed to score in a 5-0 defeat last night. Andrew Heaney took the loss after allowing five runs on eight hits with two strikeouts and three walks in 5.0 innings.

This year, the Pirates average 2.98 runs per game (30th in the MLB) on a .223/.303/.329 triple-slash. When it comes to pitching, the Pirates’ staff has a 4.03 ERA (19th) and 1.27 WHIP (17th). Bryan Reynolds leads the Pirates with a .208 batting average, six home runs, and 27 RBI this season.

The projected starting pitcher for the Pirates is Mike Burrows, who is 0-1 in one start this season, with a 7.20 ERA and 1.20 WHIP in 5.0 innings.

Arizona Diamondbacks Betting Preview

The Arizona Diamondbacks (27-27, 14-13 Home) snapped a five-game losing skid with a Game 1 win over the Pittsburgh Pirates. That five-game losing run was Arizona’s longest of the season, during which the D-backs were swept by the Cardinals and lost a series to the Dodgers. In Monday’s 5-0 victory against Pittsburgh, Josh Naylor led the offense with two RBI, while Ryne Nelson had his best start of the season as he got the win, allowing no runs on four hits with four strikeouts and no walks across 6.2 innings of work.

This season, the Diamondbacks average 5.04 runs per game (5th in the MLB) on a .256/.333/.449 triple-slash. When it comes to pitching, the Diamondbacks’ staff has a 4.59 ERA (24th) and 1.31 WHIP (19th). Eugenio Suarez leads the Diamondbacks with a .232 batting average, 15 home runs, and 41 RBI this season.

Corbin Burnes will take the mound for the Diamondbacks on Tuesday. The 30-year-old right-hander has a 3-2 record in nine starts this year with a 2.73 ERA and 1.18 WHIP in 52.2 innings.

Why the Diamondbacks will cover

Total Runs Facts

Matchup/League Facts

Pirates vs Diamondbacks Prediction

The Diamondbacks won seven of the previous ten H2H encounters, including three of the last four. I am backing the D-backs to win Game 2 with no trouble, as they will start their best pitcher, Corbin Burnes. Burnes allowed only five runs in his last five starts and recorded two shutouts in the process. He allowed a .169 BA in 118 at-bats against the Pirates in his career. In other words, he owns the Pirates. Mike Burrows, on the other hand, will get his second ever start in the MLB and his inexperience will prove costly against one of the best hitting teams in the league. Feel free to back Arizona to win and cover.

Oliver Zivic's Pick: Diamondbacks -1.5

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