Padres vs Reds Prediction 9/2/2026 Today’s MLB Picks

In this article we will formulate a Padres vs Reds prediction for this MLB game on Wednesday, September 2nd at Great American Ball Park in Cincinnati, Ohio. Let’s take a look at the prediction for this MLB matchup. 

San Diego Padres Betting Preview

The San Diego Padres are 73-66 this year after they split the first two games by scores of 5-0 and 3-4. In game two, San Diego led 2-1 in the fifth inning, but they allowed the next three runs for the loss. The Padres recorded seven hits in the game and they were led by Tatis Jr, who went 2-5 with two home runs and two RBIs. Vasquez allowed five hits and two earned runs over 4.2 innings, while Morejon picked up the loss. Prior to this series, San Diego lost all three against the Rays and two out of three against the Pirates. 

This season, San Diego has a 3.91 ERA with a 1.29 WHIP and a .241 opponent batting average, while they have scored 591 runs with a .238 batting average and a .315 on base percentage. Manny Machado has led the Padres with 24 home runs and 75 RBIs, while Gavin Sheets has added 16 home runs and 46 RBIs. The projected starting pitcher for San Diego is Casey Mize, who is 5-8 with a 3.45 ERA and a 1.10 WHIP over 109.2 innings pitched this year. 

Cincinnati Reds Betting Preview

The Cincinnati Reds are 66-73 this season after they won game two by a score of 4-3 on Tuesday night. Cincinnati tied the game at two in the fifth inning and they scored twice in the eighth to get the win. The Reds recorded eight hits and they committed one error in the game, while they were led by Bleday, who went 1-4 with one RBI. Lodolo allowed five hits and two earned runs over 6.0 innings, while Burke got the win and Pagan picked up the save. Prior to this series, Cincinnati won two out of three against the Cubs, but lost two out of three against the Giants before that. 

This season, Cincinnati has a 4.66 ERA with a 1.42 WHIP and a .252 opponent batting average, while they have scored 574 runs with a .228 batting average and a .307 on base percentage. Sal Stewart has led the Reds with 31 home runs and 105 RBIs, while Elly De La Cruz has added 21 home runs and 60 RBIs. The projected starting pitcher for Cincinnati is Brandon Williamson, who is 2-3 with a 6.11 ERA and a 1.64 WHIP over 28.0 innings pitched this season. 

Why the Cincinnati Reds will win

• The underdogs have won four of the Reds’ last six games.
• The Padres have lost five of their last six road games.
• The underdogs have covered the run line in four of the last five games between the Padres and Reds at Great American Ball Park.

Why the San Diego Padres will win

• The Reds have lost each of their last nine Wednesday day home games.
• The Padres have won seven of their last eight games against NL opponents following a loss.
• The Padres have covered the run line in each of their last 11 road games following a loss.
• The Reds have failed to cover the run line in each of their last nine Wednesday day games at Great American Ball Park.
• The Reds have trailed after 3 innings in four of their last five day games against NL opponents that held a winning record.
• The Padres have led after 5 innings in three of their last four games at Great American Ball Park against NL opponents that held a losing record.

Total Runs Facts

• Each of the Padres’ last eight games as favorites against NL opponents have gone UNDER the total runs line.
• Five of the Reds’ last six games against NL West opponents have gone UNDER the total runs line.
• There has been no run scored during the first inning in 10 of the Padres’ last 11 day games against NL opponents.
• There has been at least one run scored in the first inning in four of the Reds’ last five games.

Cincinnati Reds Player Prop Facts

• Sal Stewart has hit a home run in each of the Reds’ last two day games against opponents that held a winning record.
• Brandon Williamson has recorded five or more strikeouts in four of his last five appearances at Great American Ball Park against opponents that held a winning record.
• Sal Stewart has recorded at least one hit in each of the Reds’ last 13 games against NL opponents that held a winning record.

San Diego Padres Player Prop Facts

• Fernando Tatis Jr. has hit at least one home run in two of the Padres’ last three games as favorites against the Reds.
• Casey Mize has recorded five or more strikeouts in three of his four previous appearances with his team as a road favorite against NL opponents.
• Austin Hays has recorded at least one hit in each of his last 10 appearances in day games against NL Central teams that held a losing record.

Padres vs Reds Prediction 

Cincinnati was able to even this series at one with a win on Tuesday and they have alternated wins and losses over their last five games. The Reds are 33-37 at home this year, while the Padres are 32-38 on the road. San Diego has lost four of their last five games, but they are still sitting in the last wild card spot. The Padres are starting Mize, who has allowed two earned runs or fewer in three of his last four starts, while Williamson has allowed nine earned runs in his last 7.1 innings. Take the Padres here.

David Racey's Pick: Padres ML