Orioles vs Royals Prediction 4/22/2026 Today’s MLB Picks

In this article we will formulate an Orioles vs Royals prediction for this MLB game on Wednesday, April 22nd at Kauffman Stadium in Kansas City, Missouri. Let’s take a look at the prediction for this MLB matchup. 

Baltimore Orioles Betting Preview

The Baltimore Orioles are 11-13 this year after they split the first two games in this series by scores of 7-5 and 5-6. In game two, Baltimore led 3-0 in the second inning and 5-4 in the eighth, but they couldn’t hold either lead and ended up with the loss. The Orioles recorded eight hits in the game and they were led by Mayo, who went 1-3 with one home run and three RBIs. Baz allowed eight hits and four earned runs over 6.1 innings, while Garcia blew the save and Helsley got the loss. Prior to this series, Baltimore lost three out of four against the Guardians and two out of three against the Diamondbacks. 

This season, Baltimore has a 3.92 ERA with a 1.36 WHIP and a .250 opponent batting average, while they have scored 103 runs with a .227 batting average and a .318 on base percentage. Gunnar Henderson has led the Orioles with seven home runs and 15 RBIs, while Jeremiah Jackson has added five home runs and 17 RBIs. The projected starting pitcher for Baltimore is Chris Bassitt, who is 0-2 with a 6.19 ERA and a 2.13 WHIP over 16.0 innings pitched this year. 

Kansas City Royals Betting Preview

The Kansas City Royals are 8-16 this season after they won game two by a score of 6-5 on Tuesday night. Kansas City blew a 4-3 lead in the eighth inning, but they scored once in the eighth and once in the ninth for the comeback win. The Royals recorded 10 hits in the game and they were led by Massey, who went 2-3 with one home run and two RBIs. Bubic allowed five hits and three earned runs over 6.0 innings, while Erceg picked up the win in relief. Prior to this series, Kansas City lost all three against the Yankees and all three against the Tigers. 

This season, Kansas City has a 4.58 ERA with a 1.38 WHIP and a .234 opponent batting average, while they have scored 82 runs with a .227 batting average and a .305 on base percentage. Carter Jensen has led the Royals with five home runs and 12 RBIs, while Maikel Garcia has added two home runs and 10 RBIs. The projected starting pitcher for Kansas City is Michael Wacha, who is 2-0 with a 1.00 ERA and a 0.78 WHIP over 27.0 innings pitched this season. 

Why the Kansas City Royals will win

• The Orioles have lost each of their last four day games following a loss.
• The Royals have won each of their last three day games against AL East opponents that held a losing record.
• The Orioles have failed to cover the run line in each of their last four day games following a road loss.
• The Royals have covered the run line each of their last three day games against AL East opponents that held a losing record.
• The Royals have led after 5 innings in four of their last five games at Kauffman Stadium.
• The Orioles have trailed after 3 innings in three of their last four day games against AL Central opponents.

Why the Baltimore Orioles will win

• The Royals have lost four of their last five games as favorites following a home win.
• The Orioles have won seven of their last eight road games against teams that held a losing record.
• The Royals have failed to cover the run line in each of their last six games against American League opponents.
• The Orioles have covered the run line in seven of their last eight road games against American League opponents that held a losing record.
• The Orioles have led after 5 innings in four of their last five day games at Kauffman Stadium against American League opponents.
• The Orioles have led after 3 innings in three of their last four games against opponents that held a losing record.

Total Runs Facts

• Four of the Orioles’ last five road games have gone OVER the total runs line.
• Four of the Royals’ last five home games against AL East opponents have gone OVER the total runs line.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the Orioles’ last six day games against AL Central opponents.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in nine of the Royals’ last 10 home games against AL East opponents.

Orioles vs Royals Prediction 

Kansas City finally snapped their losing streak with a comeback victory on Tuesday night, but they have allowed 32 runs in their last four games. The Royals are 6-6 at home this year, while the Orioles are 5-7 on the road. Baltimore has lost three of their last four games and they have allowed 19 runs in their last three. Neither pitching staff has been very good recently, but Wacha has some elite numbers to start the season. Take Kansas City to get another win here.

David Racey's Pick: Royals ML