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Oakland Athletics vs Arizona Diamondbacks Prediction 7/21/2026 Today’s MLB Picks

Jun 2, 2026; Phoenix, Arizona, USA; Arizona Diamondbacks second baseman Ketel Marte hits a sacrifice fly to drive in a run in the fifth inning against the Los Angeles Dodgers at Chase Field. Mandatory Credit: Mark J. Rebilas-Imagn Images

Jun 2, 2026; Phoenix, Arizona, USA; Arizona Diamondbacks second baseman Ketel Marte hits a sacrifice fly to drive in a run in the fifth inning against the Los Angeles Dodgers at Chase Field. Mandatory Credit: Mark J. Rebilas-Imagn Images

MATCHUP Oakland Athletics Arizona Diamondbacks
Team Records 42-57 51-49
Spread +1.5 -182 -1.5 150
Moneyline +114 -137
Total Over 9.5 (-115) Under 9.5 (-105)
Where Chase Field, Phoenix, Arizona
When Tuesday, July 21, 2026
Time 09:40 PM EDT
TV MLB.TV

In this article, we will formulate an Athletics vs Diamondbacks Prediction for this MLB matchup on Tuesday, July 21st in the second game of this series. Let’s take a look at the prediction for this MLB matchup.

Arizona Diamondbacks Preview

The Arizona Diamondbacks have a 51-49 record this season and are sitting in the 2nd place of the NL West. They have a 29-22 home record and are coming off a 2-5 home loss against the Athletics. They will face the Nationals and the Pirates next.

The Arizona Diamondbacks have a .237 batting average this season, .308 OBP and .387 Slugging percentage. Arizona’s pitching staff has a 4.22 ERA and 1.29 WHIP. Ketel Marte is the team’s best hitter with a .258 batting average, leads the team in RBI with 58, and adds a team-high 18 home runs.

The Diamondbacks have not yet announced a starting pitcher for this game.

Athletics Preview

The Athletics have a 43-57 record this season and are sitting in the 4th place of the AL West. They have a 23-27 away record and are coming off a 5-2 road win against the Diamondbacks. They will face the Twins and the Red Sox next.

The Athletics have a .247 batting average this season, .324 OBP and .406 Slugging percentage. Oakland’s pitching staff has a 5.29 ERA and 1.48 WHIP. Nick Kurtz is the team’s best hitter with a .266 batting average, adding a team-high 66 RBI. Shea Langeliers adds a team-high 22 home runs.

Jack Perkins (R) is the projected starting pitcher for the Athletics, and he has a 2-5 record, 6.87 ERA and 1.44 WHIP.

Athletics @ Arizona Diamondbacks Betting Trends: July 21, 2026

Why the Arizona Diamondbacks will win

Why the Athletics will win

Total Runs Facts

Arizona Diamondbacks Player Prop Facts

Athletics Player Prop Facts

Matchup/League Facts

Athletics vs Diamondbacks Prediction

The Diamondbacks are 4-2 in their last 6 meetings against the A’s and have won two of their last three meetings in Arizona.  

In this Athletics vs Diamondbacks Prediction, the Diamondbacks are coming as -135 home favorites. I like the Dbacks in a bounce back spot today no matter who will be on the mound, as the A’s have been one of the worst teams in baseball lately, with their bullpen ranking dead last in the league. Jack Perkins has been terrible with a 9.26 ERA across his last three starts and the A’s have lost seven of the eight games he has taken the bump. Take the Dbacks to win this one at home.

Nikos Lagouretos's Pick: Arizona Diamondbacks ML

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